Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120539
Full metadata record
DC FieldValueLanguage
dc.creatorAlmeida J.R.
dc.creatorCorreia-Da-Silva M.
dc.creatorSousa E.
dc.creatorAntunes J.
dc.creatorPinto M.
dc.creatorVasconcelos V.
dc.creatorCunha I.
dc.date.accessioned2019-05-31T16:16:55Z-
dc.date.available2019-05-31T16:16:55Z-
dc.date.issued2017
dc.identifier.issn20452322
dc.identifier.urihttps://hdl.handle.net/10216/120539-
dc.description.abstractNatural products with a sulfated scaffold have emerged as antifouling agents with low or nontoxic effects to the environment. In this study 13 sulfated polyphenols were synthesized and tested for antifouling potential using the anti-settlement activity of mussel (Mytilus galloprovincialis) plantigrade post-larvae and bacterial growth inhibition towards four biofilm-forming bacterial strains. Results show that some of these Nature-inspired compounds were bioactive, particularly rutin persulfate (2), 3,6-bis(β-D-glucopyranosyl) xanthone persulfate (6), and gallic acid persulfate (12) against the settlement of plantigrades. The chemical precursors of sulfated compounds 2 and 12 were also tested for anti-settlement activity and it was possible to conclude that bioactivity is associated with sulfation. While compound 12 showed the most promising anti-settlement activity (EC50 = 8.95 μg.mL-1), compound 2 also caused the higher level of growth inhibition in bacteria Vibrio harveyi (EC20 = 12.5 μg.mL-1). All the three bioactive compounds 2, 6, and 12 were also found to be nontoxic to the non target species Artemia salina (<10% mortality at 250 μM) and Vibrio fischeri (LC50 > 1000 μg.mL-1). This study put forward the relevance of synthesizing non-natural sulfated small molecules to generate new nontoxic antifouling agents. © 2017 The Author(s).
dc.description.sponsorshipThe authors thank to Elisabete Silva from the FFCUL for the ECONEA® sample. This research was supported by Fundação para a Ciência e Tecnologia (FCT), Projeto 9471 – Reforçar a Investigação, o Desenvolvimento Tecnológico e a Inovação (RIDTI) and by Fundo Comunitário Europeu FEDER - PTDC/AAG-TEC/0739/2014 (POCI-01-0145-FEDER-016793) under the project PTDC/AAG-TEC/0739/2014 (POCI-01-0145-FEDER-016793), and through a postdoctoral scholarship to J.R.A. (SFRH/BPD/87416/2012), to M.C.d.S. (SFRH/BPD/81878/2011), and a PhD scholarship to J.A. (SFRH/BD/ 99003/2013).
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports, vol. 7():42424
dc.rightsrestrictedAccess
dc.titleAntifouling potential of Nature-inspired sulfated compounds
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoCIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
dc.identifier.doi10.1038/srep42424
dc.relation.publisherversionhttp://dx.doi.org/10.1038/srep42424
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
Almeida JR_2017.pdf
  Restricted Access
857.46 kBAdobe PDF    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.