Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120504
Author(s): Prompanya C.
Dethoup T.
Gales L.
Lee M.
Pereira J.A.C.
Silva A.M.S.
Pinto M.M.M.
Kijjoa A.
Title: New polyketides and new benzoic acid derivatives from the marine sponge-associated fungus Neosartorya quadricincta KUFA 0081
Publisher: MDPI
Issue Date: 2016
Abstract: Two new pentaketides, including a new benzofuran-1-one derivative (1) and a new isochromen-1-one (5), and seven new benzoic acid derivatives, including two new benzopyran derivatives (2a, b), a new benzoxepine derivative (3), two new chromen-4-one derivatives (4b, 7) and two new benzofuran derivatives (6a, b), were isolated, together with the previously reported 2,3-dihydro-6-hydroxy-2,2-dimethyl-4H-1-benzopyran-4-one (4a), from the culture of the marine sponge-associated fungus Neosartorya quadricincta KUFA 0081. The structures of the new compounds were established based on 1D and 2D NMR spectral analysis, and in the case of compounds 1, 2a, 4b, 5, 6a and 7, the absolute configurations of their stereogenic carbons were determined by an X-ray crystallographic analysis. None of the isolated compounds were active in the tests for antibacterial activity against Gram-positive and Gram-negative bacteria, as well as multidrug-resistant isolates from the environment (MIC > 256 μg/mL), antifungal activity against yeast (Candida albicans ATTC 10231), filamentous fungus (Aspergillus fumigatus ATTC 46645) and dermatophyte (Trichophyton rubrum FF5) (MIC > 512 μg/mL) and in vitro growth inhibitory activity against the MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma) cell lines (GI50 > 150 μM) by the protein binding dye SRB method. © 2016 by the authors; licensee MDPI.
Subject: 2,3 dihydro 6 hydroxy 2,2 dimethyl 4h 1 benzopyran 4 one
3 hydroxy 3 methyl 2,3 dihydro 1 benzoxepine 7 carboxylic acid
benzofuran 1 one derivative
benzofuran derivative
benzoic acid derivative
benzopyran derivative
benzoxepin derivative
chromen 4 one derivative
isochromen 1 one
polyketide
quadricinctafuran A
quadricinctapyran A
quadricinctone A
quadricinctone B
quadricinctone C
quadricinctone D
unclassified drug
A375 cell line
antibacterial activity
antifungal activity
Aspergillus fumigatus
Candida albicans
fungal strain
fungus culture
GI50
Gram negative bacterium
Gram positive bacterium
human
isolation procedure
lung cancer cell line
marine species
MCF 7 cell line
minimum inhibitory concentration
multidrug resistance
Neosartorya
Neosartorya quadricincta
non small cell lung cancer
nonhuman
nuclear magnetic resonance spectroscopy
Review
sponge (Porifera)
structure analysis
Trichophyton rubrum
X ray crystallography
URI: https://hdl.handle.net/10216/120504
Source: Marine Drugs, vol. 14(7):134
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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