Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120500
Author(s): Noinart J.
Buttachon S.
Dethoup T.
Gales L.
Pereira J.A.
Urbatzka R.
Freitas S.
Lee M.
Silva A.M.S.
Pinto M.M.M.
Vasconcelos V.
Kijjoa A.
Title: A new ergosterol analog, a new bis-anthraquinone and anti-obesity activity of anthraquinones from the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207
Publisher: MDPI
Issue Date: 2017
Abstract: A new ergosterol analog, talarosterone (1) and a new bis-anthraquinone derivative (3) were isolated, together with ten known compounds including palmitic acid, ergosta-4,6,8(14),22- tetraen-3-one, ergosterol-5,8-endoperoxide, cyathisterone (2), emodin (4a), questinol (4b), citreorosein (4c), fallacinol (4d), rheoemodin (4e) and secalonic acid A (5), from the ethyl acetate extract of the culture of the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207. The structures of the new compounds were established based on extensive 1D and 2D spectral analysis, and in the case of talarosterone (1), the absolute configurations of its stereogenic carbons were determined by X-ray crystallographic analysis. The structure and stereochemistry of cyathisterone (2) was also confirmed by X-ray analysis. The anthraquinones 4a-e and secalonic acid A (5) were tested for their anti-obesity activity using the zebrafish Nile red assay. Only citreorosein (4c) and questinol (4b) exhibited significant anti-obesity activity, while emodin (4a) and secalonic acid A (5) caused toxicity (death) for all exposed zebrafish larvae after 24 h. © 2017 by the authors. Licensee MDPI.
Subject: anthraquinone derivative
citreorosein
cyathisterone
emodin
ergosta 4,6,8(14),22 tetraen 3 one
ergosterol 5,8 endoperoxide
fallacinol
palmitic acid
questinol
resveratrol
rheoemodin
secalonic acid A
sterol derivative
talarosterone
unclassified drug
adult
animal experiment
Article
controlled study
crystal structure
drug structure
embryo
nonhuman
obesity
sponge (Porifera)
stereochemistry
Stylissa flabelliformis
Talaromyces
Talaromyces stipitatus
X ray crystallography
zebra fish
URI: https://hdl.handle.net/10216/120500
Source: Marine Drugs, vol. 15(5):
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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