Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120471
Author(s): Kabeya N.
Fonseca M.M.
Ferrier D.E.K.
Navarro J.C.
Bay L.K.
Francis D.S.
Tocher D.R.
Castro L.F.C.
Monroig O.
Title: Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals
Publisher: American Association for the Advancement of Science
Issue Date: 2018
Abstract: Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desaturases. ωx desaturases have also been described in a small number of invertebrate animals, but their precise distribution has not been systematically explored. This study identifies 121 ωx desaturase sequences from 80 species within the Cnidaria, Rotifera, Mollusca, Annelida, and Arthropoda. Horizontal gene transfer has contributed to this hitherto unknown widespread distribution. Functional characterization of animal ωx desaturases provides evidence that multiple invertebrates have the ability to produce ω3 PUFA de novo and further biosynthesize ω3 long-chain PUFA. This finding represents a fundamental revision in our understanding of ω3 long-chain PUFA production in global food webs, by revealing that numerous widespread and abundant invertebrates have the endogenous capacity to make significant contributions beyond that coming from marine microbes. Copyright © 2018 The Authors, some rights reserved.
Subject: Animals
Bacteria
Biochemistry
Chains
Ecosystems
Gene transfer
Genes
Endogenous capacities
Essential nutrients
Functional characterization
Horizontal gene transfer
Invertebrate animals
Long chain polyunsaturated fatty acid
Marine microbe
Omega-3 polyunsaturated fatty acids
Polyunsaturated fatty acids
URI: https://hdl.handle.net/10216/120471
Source: Science Advances, vol. 4(5): eaar6849
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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