Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120467
Author(s): Guzmán-Guillén R.
Puerto M.
Gutiérrez-Praena D.
Prieto A.I.
Pichardo S.
Jos Á.
Campos A.
Vasconcelos V.
Cameán A.M.
Title: Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review
Publisher: MDPI
Issue Date: 2017
Abstract: Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research on MCs is much more abundant than research on CYN. Among chemoprotectants, antioxidant compounds are the most extensively studied, probably because it is well known that oxidative stress is one of the toxic mechanisms common to both toxins. In this group, vitamin E seems to have the strongest protectant effect for both cyanotoxins. Transport inhibitors have also been studied in the case of MCs, as CYN cellular uptake is not yet fully elucidated. Further research is needed because systematic studies are lacking. Moreover, more realistic exposure scenarios, including cyanotoxin mixtures and the concomitant use of chemoprotectants, should be considered. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Subject: acetylcysteine
alpha tocopherol
amifostine
ascorbic acid
aurantiin
bacterial toxin
carnitine
cyanotoxin
cyclosporin A
cylindrospermopsin
cysteine
cytochalasin
epigallocatechin gallate
glutathione
melatonin
microcystin
osmotic agent
rifampicin
silymarin
sulforaphane
thioctic acid
trolox C
unclassified drug
heart failure
human
intoxication
liver hemorrhage
liver injury
nonhuman
oxidative stress
Review
tumor promotion
URI: https://hdl.handle.net/10216/120467
Source: Toxins, vol. 9(6):175
Related Information: info:eu-repo/grantAgreement/FCT/5876/147268/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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