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Author(s): Gezici S.
Sekeroglu N.
Kijjoa A.
Title: In vitro anticancer activity and antioxidant properties of essential oils from Populus alba L. and Rosmarinus officinalis L. from South Eastern Anatolia of Turkey
Publisher: Emanuscript Services
Issue Date: 2017
Abstract: Background and Purpose: In recent years, essential oils (EOs) have been reported to possess interesting anti-tumor, anti-mutagenic and anti-carcinogenic activities against various cancer cells. Therefore, we aimed to investigate potential biological activities of EOs from white poplar (Populus alba L., Salicaceae) and rosemary (Rosmarinus officinalis L., Lamiaceae). Material and Methods: EOs from P. alba L. and R. officinalis L. were extracted by hydrodistillation. MTT assay was carried out to determine the potential antiproliferative and cytotoxic properties of the essential oils as well as their corresponding IC50, and the inhibition (%) calculated. Antioxidant activity was determined using 2,2-diphenyl-2-picrylhydrazyl (DPPH) assay, and lipid peroxidation capacity was evaluated using thiobarbituric acid-reactive substances (TBARS) method, and the values were calculated using the standards. Results: The EOs were evaluated for their in vitro cytotoxic, antioxidant and lipid oxidation activities. Regarding cytotoxic activity rosemary essential oil possessed strong inhibition (IC50 = 3.06-7.38 µg/mL) of cell proliferation in comparison to that of P. alba L. (IC50 = 10.53-28.16 µg/mL). Additionally, EO from R. officinalis L. was found to have higher antioxidant and lipid peroxidation capacities with IC50 of 10.08 ± 0.15 and 1.76 ± 0.01, respectively. Conclusion: The results suggest that the EOs of both sources exhibited strong antiproliferative, cytotoxic and potent antioxidant properties and therefore they can have potential applications in the cancer treatment. © 2017, Association of Pharmaceutical Teachers of India. All rights reserved.
Subject: essential oil
thiobarbituric acid reactive substance
A-549 cell line
antineoplastic activity
antioxidant activity
antiproliferative activity
comparative study
controlled study
DPPH radical scavenging assay
drug cytotoxicity
human cell
in vitro study
lipid oxidation
lipid peroxidation assay
MCF-7 cell line
mitosis inhibition
NCI-H1299 cell line
Populus alba
Turkey (republic)
Source: Indian Journal of Pharmaceutical Education and Research, vol. 51(3), p. S498-S503
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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