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Author(s): Zin W.W.M.
Buttachon S.
Dethoup T.
Pereira J.A.
Gales L.
Inácio Â.
Costa P.M.
Lee M.
Sekeroglu N.
Silva A.M.S.
Pinto M.M.M.
Kijjoa A.
Title: Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA 0006
Publisher: Elsevier
Issue Date: 2017
Abstract: Five previously undescribed metabolites, including acetylquestinol, two prenylated indole 3-carbaldehyde derivatives, an anthranilic acid derivative and an isochromone derivative, were isolated, in addition to eleven known compounds: palmitic acid, ergosterol 5,8-endoperoxide, emodin, physcion, questin, questinol, (11S, 14R)-cyclo(tryptophylvalyl), preechinulin, neoechinulin E, echinulin and eurocristatine, from the culture of the endophytic fungus Eurotium chevalieri KUFA 0006. The structures of the previously undescribed compounds were established based on an extensive 1D and 2D NMR spectral analysis as well as HRMS and IR data. In case of 2-(2, 2-dimethylcyclopropyl)-1H-indole-3-carbaldehyde and 6, 8-dihydroxy-3-(2S-hydroxypropyl)-7-methylisochromone, the absolute configurations of their stereogenic carbons were established based on comparison of their experimental and calculated ECD spectra. All the compounds, except for palmitic acid and ergosterol 5, 8-endoperoxide, were evaluated for their antibacterial and antibiofilm activities against two Gram-positive and two Gram-negative bacteria, as well as multidrug-resistant isolates from the environment. Emodin not only exhibited moderate antibacterial activity against the Gram-positive bacteria but also showed strong synergistic association with oxacillin against MRSA Staphylococcus aureus. © 2017 Elsevier
Subject: anthranilic acid
anthranilic acid derivative
anthraquinone derivative
antiinfective agent
chromone derivative
indole derivative
chemical structure
drug effects
isolation and purification
methicillin resistant Staphylococcus aureus
microbial sensitivity test
Anti-Bacterial Agents
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Molecular Structure
Source: Phytochemistry, vol. 141, p. 86-97
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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