Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/120448
Author(s): | Silva B. Fernandes C. de Pinho P.G. Remião F. |
Title: | Chiral resolution and enantioselectivity of synthetic cathinones: A brief review |
Publisher: | Oxford University Press |
Issue Date: | 2018 |
Abstract: | Chiral discrimination has become one of the most important fields in analytical and medicinal chemistry, and forensic toxicology. The enantiomers may have different binding to proteins that may lead to many pharmacological and toxicological differences between them, including kinetic (at the absorption, distribution, metabolism and excretion level) or dynamic (level of potency and efficacy or even differences in mechanism of action) variations. Cathinone derivatives are chiral compounds, sold via the internet for recreational use, and little is known about their enantiomeric selectivity. Consequently, it is of crucial importance for the development of resolution methods to obtain pure enantiomers to study their biological effects. In the last few years, techniques for chiral drug analysis, as chromatography, have been developed and some works related to the analytical enantiomeric resolution of synthetic cathinones were described. However, information about synthetic cathinones in the literature is scarce specially concerning single enantiomers. In this mini-review, analytical chiral resolution and biological differences between enantiomers of cathinone derivatives will be addressed. © The Author 2017. Published by Oxford University Press. All rights reserved. |
Subject: | 4' methylmethcathinone cathinone drug metabolite methylenedioxypyrovalerone neurotransmitter unclassified drug alkaloid cathinone psychotropic agent animal behavior chiral chromatography chirality enantiomer enantioselectivity human hyperthermic effect liver cell liver toxicity metabolite mouse nonhuman primary cell culture rat Review synthesis Turbellaria animal drug dependence isomerism procedures structure activity relation substance abuse synthesis Alkaloids Animals Humans Isomerism Psychotropic Drugs Structure-Activity Relationship Substance Abuse Detection Substance-Related Disorders |
URI: | https://hdl.handle.net/10216/120448 |
Source: | Journal of Analytical Toxicology, vol. 42(1), p. 17-24 |
Related Information: | info:eu-repo/grantAgreement/FCT/5876/147268/PT |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Silva B_2018.pdf Restricted Access | 258.89 kB | Adobe PDF | Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.