Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120355
Author(s): Ledoux J.-B.
Antunes A.
Title: Beyond the beaten path: improving natural products bioprospecting using an eco-evolutionary framework–the case of the octocorals
Publisher: Taylor & Francis
Issue Date: 2018
Abstract: Marine natural products (NPs) represent an impressive source of novel bioactive molecules with major biotechnological applications. Nevertheless, the usual chemical and applied perspective leading most of bioprospecting projects come along with various limitations blurring our understanding of the extensive marine chemical diversity. Here, we propose several guidelines: (i) to optimize bioprospecting and (ii) to refine our knowledge on marine chemical ecology focusing on octocorals, one of the most promising sources of marine NPs. We identified a significant phylogenetic bias in the octocoral bioprospecting, which calls for the development of a concerted discovery strategy. Given the gap existing between the number of isolated NPs and the knowledge regarding their functions, we provide an ecologically centered workflow prioritizing biological function ahead of chemical identification. Furthermore, we illustrate how -omic technologies should rapidly increase our knowledge on solving different aspects of the ecology and evolution of marine NPs. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Subject: Bioassay
Biochemistry
Biology
Ecology
Metabolites
Chemical ecology
concerted discovery strategy
Ecological functions
Evolutionary process
In-silico
metagenomic
Natural products
Octocoral
transcriptomic
Marine applications
natural product
biological product
bioprospecting
biosynthesis
biotechnology
coral
ecology
omics
phylogeny
priority journal
Review
taxonomic rank
animal
Anthozoa
bioprospecting
classification
genetics
metabolism
Animals
Anthozoa
Biological Products
Bioprospecting
Phylogeny
URI: https://hdl.handle.net/10216/120355
Source: Critical Reviews in Biotechnology, vol. 38(2), p. 184-198
Related Information: info:eu-repo/grantAgreement/FCT/5876/147268/PT
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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