Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120347
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dc.creatorGuzmán-Guillén R.
dc.creatorPrieto Ortega A.I.
dc.creatorMoyano R.
dc.creatorBlanco A.
dc.creatorVasconcelos V.
dc.creatorCameán A.M.
dc.date.accessioned2019-05-31T16:14:56Z-
dc.date.available2019-05-31T16:14:56Z-
dc.date.issued2017
dc.identifier.issn15204081, 15227278
dc.identifier.urihttps://hdl.handle.net/10216/120347-
dc.description.abstractCylindrospermopsin (CYN) is a cytotoxin highly water-soluble, which is easily taken up by several aquatic organisms. CYN acts as a potent protein and glutathione synthesis inhibitor, as well as inducing genotoxicity, oxidative stress, and histopathological alterations. This is the first study reporting the protective effect of a l-carnitine (LC) pretreatment (400 or 880 mg LC/kg bw fish/day, for 21 days) on the histopathological alterations induced by pure CYN or Aphanizomenon ovalisporum lyophilized cells (400 µg CYN/kg bw fish) in liver, kidney, heart, intestines, and gills of tilapia (Oreochromis niloticus) acutely exposed to the toxin by oral route. The main histopathological changes induced by CYN were disorganized parenchyma with presence of glycogen and lipids in the cytoplasm (liver), glomerulonephritis, glomerular atrophy, and dilatation of Bowman's capsule (kidney), myofibrolysis, loss of myofibrils, with edema and hemorrhage (heart), intestinal villi with necrotic enterocytes and partial loss of microvilli (gastrointestinal tract), and hyperemia and hemorrhage (gills). LC pretreatment was able to totally prevent those CYN-induced alterations from 400 mg LC/kg bw fish/day in almost all organs, except in the heart, where 880 mg LC/kg bw fish/day were needed. In addition, the morphometric study indicated that LC managed to recover totally the affectation in the cross sections of the proximal and distal convoluted tubules in CYN-exposed fish. © 2015 Wiley Periodicals, Environ Toxicol 32: 241–254, 2017. © 2015 Wiley Periodicals,
dc.description.sponsorshipThe authors would like to acknowledge the European Cooperation in Science and Technology, COST Action ES 1105 “CYANOCOST‐Cyanobacterial blooms and toxins in water resources: Occurrence, impacts, and management” for adding value to this study through networking and knowledge sharing with European experts and researchers in the field. Remedios Guzmán Guillén also gratefully acknowledges the Spanish Ministerio de Educación for her grant “Formación del Profesorado Universitario (FPU).”
dc.language.isoeng
dc.publisherJohn Wiley and Sons
dc.relation.ispartofEnvironmental Toxicology, vol. 32(1), p. 241-254
dc.rightsrestrictedAccess
dc.subjectAquatic organisms
dc.subjectBiosynthesis
dc.subjectCytology
dc.subjectAphanizomenon ovalisporum
dc.subjectCylindrospermopsin
dc.subjectHistopathology
dc.subjectL-carnitine
dc.subjectTilapia
dc.subjectFish
dc.subjectcarnitine
dc.subjectcylindrospermopsin
dc.subjectglycogen
dc.subjectlipid
dc.subjectbacterial toxin
dc.subjectcarnitine
dc.subjectcylindrospermopsin
dc.subjectprotective agent
dc.subjecturacil
dc.subjectwater pollutant
dc.subjectcichlid
dc.subjectcyanobacterium
dc.subjectcytology
dc.subjectcytoplasm
dc.subjectdiet
dc.subjectgenotoxicity
dc.subjecthistopathology
dc.subjectinhibitor
dc.subjectmorphometry
dc.subjectoxidative stress
dc.subjectprotein
dc.subjecttoxin
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectbleeding
dc.subjectBowman capsule
dc.subjectcontrolled study
dc.subjectcytoplasm
dc.subjectdiet supplementation
dc.subjectfreeze drying
dc.subjectgenotoxicity
dc.subjectgill
dc.subjectglomerulonephritis
dc.subjectglutathione metabolism
dc.subjectheart
dc.subjecthistopathology
dc.subjecthyperemia
dc.subjectintestine
dc.subjectintestine cell
dc.subjectkidney
dc.subjectkidney distal tubule
dc.subjectliver
dc.subjectmuscle fibril
dc.subjectnonhuman
dc.subjectOreochromis niloticus
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectanalogs and derivatives
dc.subjectanimal
dc.subjectAphanizomenon
dc.subjectcardiac muscle
dc.subjectcichlid
dc.subjectdiet
dc.subjectdrug effects
dc.subjectelectron microscopy
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectpathology
dc.subjecttoxicity
dc.subjectwater pollutant
dc.subjectAphanizomenon ovalisporum
dc.subjectOreochromis niloticus
dc.subjectTilapia
dc.subjectAnimals
dc.subjectAphanizomenon
dc.subjectBacterial Toxins
dc.subjectCarnitine
dc.subjectCichlids
dc.subjectDiet
dc.subjectGills
dc.subjectHeart
dc.subjectKidney
dc.subjectLiver
dc.subjectMicroscopy, Electron
dc.subjectMyocardium
dc.subjectOxidative Stress
dc.subjectProtective Agents
dc.subjectUracil
dc.subjectWater Pollutants
dc.titleDietary l-carnitine prevents histopathological changes in tilapia (Oreochromis Niloticus) exposed to cylindrospermopsin
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoCIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
dc.identifier.doi10.1002/tox.22229
dc.relation.publisherversionhttp://dx.doi.org/10.1002/tox.22229
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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