Please use this identifier to cite or link to this item:
Author(s): Fonseca E.
Ruivo R.
Lopes-Marques M.
Zhang H.
Santos M.M.
Venkatesh B.
Castro L.F.C.
Title: LXRα and LXRβ nuclear receptors evolved in the common ancestor of gnathostomes
Publisher: Oxford University Press
Issue Date: 2017
Abstract: Nuclear receptors (NRs) regulate numerous aspects of the endocrine system. They mediate endogenous and exogenous cues, ensuring a homeostatic control of development and metabolism. Gene duplication, loss and mutation have shaped the repertoire and function of NRs in metazoans. Here, we examine the evolution of a pivotal orchestrator of cholesterol metabolism in vertebrates, the liver X receptors (LXRs). Previous studies suggested that LXRα and LXRβ genes emerged in themammalian ancestor. However, we show through genomean alysis and functional assay that bona fide LXRα and LXRβ orthologues are present in reptiles, coelacanth and chondrichthyans but not in cyclostomes. These findings show that LXR duplicated before gnathostome radiation, followed by asymmetric paralogue loss in some lineages. We suggest that a tighter control of cholesterol levels in vertebrates was achieved through the exploitation of a wider range of oxysterols, an ability contingent on ligand-binding pocket remodeling. © 2016 The Author.
Subject: cholesterol
helminth protein
liver X receptor
lipid metabolism
molecular evolution
Evolution, Molecular
Helminth Proteins
Lipid Metabolism
Liver X Receptors
Source: Genome Biology and Evolution, vol. 9(1), p. 222-230
Related Information: info:eu-repo/grantAgreement/FCT/5876/147268/PT
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
Fonseca E_2017.pdf
  Restricted Access
1.36 MBAdobe PDF    Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.