1. Repositório Aberto da Universidade do Porto
  2. CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
  3. CIIMAR - Artigo em Revista Científica Internacional
Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120309
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dc.creatorCosta M.L.
dc.creatorRodrigues J.A.
dc.creatorAzevedo J.
dc.creatorVasconcelos V.
dc.creatorEiras E.
dc.creatorCampos M.G.
dc.date.accessioned2019-05-31T16:14:38Z-
dc.date.available2019-05-31T16:14:38Z-
dc.date.issued2018
dc.identifier.issn410101
dc.identifier.urihttps://hdl.handle.net/10216/120309-
dc.description.abstractA 67-year-old Caucasian male with lung cancer was presented to the Emergency Department with asthenia, anorexia, jaundice and choluria. The patient's lung cancer was being treated medically by a combination of paclitaxel/carboplatin with bi-monthly frequency. The patient was also self-medicating with several natural products, including Chlorella (520 mg/day), Silybum marianum (total of 13.5 mg silymarin/day), zinc sulphate (5.5 mg), selenium (50 μg) and 15 g/day of Curcuma longa. In first chemotherapy cycle no toxicity was observed even he was taking other medications as budesonide and sitagliptin. The toxic events started only after the introduction of the dietary products. Chlorella had contamination with cyanobacteria (Oscillatoriales) and 1.08 μg of cyanotoxin Microcystin-LR (MC-LR) per gram of biomass was found. Patient was consuming ca 0.01 μg MC-LR/kg/day. This case report describes the first known case of paclitaxel toxicity probably related to pharmacokinetic interaction with Turmeric and a contaminated Chlorella supplement resulting in an acute toxic hepatitis and the impact on oncologic patient health. © 2018 Elsevier
dc.description.sponsorshipThis work was supported by QREN , under the scope of POFC – COMPETE, Project n°16872 & FCT Project - PEst-OE/SAU/UI0177/2011 & FCT Project UID/Multi/04423/2013 & FCT UID/QUI/00313/2013 and by the Structured Program of R&D&I INNOVMAR - Innovation and Sustainability in the Management and Exploitation of Marine Resources (reference NORTE-01-0145-FEDER-000035 , Research Line NOVELMAR), funded by the Northern Regional Operational Program ( NORTE2020 ) through the European Regional Development Fund (ERDF). The authors are grateful to Cátia Costa that did the figure n° 1 for this publication.
dc.language.isoeng
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147268/PT
dc.relation.ispartofToxicon, vol. 150, p. 207-211
dc.rightsrestrictedAccess
dc.subjectalanine aminotransferase
dc.subjectalfuzosin
dc.subjectantihistaminic agent
dc.subjectaspartate aminotransferase
dc.subjectatorvastatin
dc.subjectbilirubin
dc.subjectbudesonide
dc.subjectcarboplatin
dc.subjectChlorella extract
dc.subjectCurcuma longa extract
dc.subjectformoterol
dc.subjectmetformin
dc.subjectmetformin plus sitagliptin
dc.subjectmicrocystin
dc.subjectmicrocystin LR
dc.subjectnatural product
dc.subjectpaclitaxel
dc.subjectselenium
dc.subjectSilybum marianum extract
dc.subjectsitagliptin
dc.subjecttiotropium bromide
dc.subjectturmeric
dc.subjectzinc sulfate
dc.subjectmicrocystin
dc.subjectpaclitaxel
dc.subjectaged
dc.subjectalanine aminotransferase blood level
dc.subjectanorexia
dc.subjectArticle
dc.subjectaspartate aminotransferase blood level
dc.subjectasthenia
dc.subjectbilirubin blood level
dc.subjectbiomass
dc.subjectcancer chemotherapy
dc.subjectcase report
dc.subjectcholuria
dc.subjectclinical article
dc.subjectcyanobacterium
dc.subjectdietary supplement
dc.subjectdisease association
dc.subjectdrug withdrawal
dc.subjectdyslipidemia
dc.subjecterythema
dc.subjectfood contamination
dc.subjecthuman
dc.subjecthypertransaminasemia
dc.subjectjaundice
dc.subjectlaboratory test
dc.subjectliver toxicity
dc.subjectlung adenocarcinoma
dc.subjectlung emphysema
dc.subjectmale
dc.subjectmultiple cycle treatment
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectpatient attitude
dc.subjectpriority journal
dc.subjectprostate hypertrophy
dc.subjectpruritus
dc.subjectself medication
dc.subjectchemistry
dc.subjectChlorella
dc.subjectCurcuma
dc.subjectdietary supplement
dc.subjectdrug contamination
dc.subjectdrug effect
dc.subjectenzymology
dc.subjectherb drug interaction
dc.subjectisolation and purification
dc.subjectliver
dc.subjecttoxic hepatitis
dc.subjectAged
dc.subjectChemical and Drug Induced Liver Injury
dc.subjectChlorella
dc.subjectCurcuma
dc.subjectCyanobacteria
dc.subjectDietary Supplements
dc.subjectDrug Contamination
dc.subjectHerb-Drug Interactions
dc.subjectHumans
dc.subjectLiver
dc.subjectMale
dc.subjectMicrocystins
dc.subjectPaclitaxel
dc.titleHepatotoxicity induced by paclitaxel interaction with turmeric in association with a microcystin from a contaminated dietary supplement
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoCIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
dc.identifier.doi10.1016/j.toxicon.2018.05.022
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.toxicon.2018.05.022
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