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dc.creatorCarvalho M.F.
dc.creatorOliveira R.S.
dc.date.accessioned2019-05-31T16:14:35Z-
dc.date.available2019-05-31T16:14:35Z-
dc.date.issued2016
dc.identifier.issn07388551, 15497801
dc.identifier.urihttps://hdl.handle.net/10216/120302-
dc.description.abstractFluorinated compounds are finding increasing uses in several applications. They are employed in almost all areas of modern society. These compounds are all produced by chemical synthesis and their abundance highly contrasts with fluorinated molecules of natural origin. To date, only some plants and a handful of actinomycetes species are known to produce a small number of fluorinated compounds that include fluoroacetate (FA), some ω-fluorinated fatty acids, nucleocidin, 4-fluorothreonine (4-FT), and the more recently identified (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid. This largely differs from other naturally produced halogenated compounds, which totals more than 5000. The mechanisms underlying biological fluorination have been uncovered after discovering the first actinomycete species, Streptomyces cattleya, that is capable of producing FA and 4-FT, and a fluorinase has been identified as the enzyme responsible for the formation of the C–F bond. The discovery of this enzyme has opened new perspectives for the biotechnological production of fluorinated compounds and many advancements have been achieved in its application mainly as a biocatalyst for the synthesis of [18F]-labeled radiotracers for medical imaging. Natural fluorinated compounds may also be derived from abiogenic sources, such as volcanoes and rocks, though their concentrations and production mechanisms are not well known. This review provides an outlook of what is currently known about fluorinated compounds with natural origin. The paucity of these compounds and the biological mechanisms responsible for their production are addressed. Due to its relevance, special emphasis is given to the discovery, characterization and biotechnological potential of the unique fluorinase enzyme. © 2016 Informa UK Limited, trading as Taylor & Francis Group
dc.description.sponsorshipM. F. Carvalho acknowledges Investigator FCT program supported by Fundação para a Ciência e a Tecnologia (FCT), Fundo Social Europeu (FSE), and Programa Operacional Potencial Humano. R. S. Oliveira wishes to acknowledge the support of FCT through the research grant SFRH/BPD/85008/2012, FSE and Programa Operacional Capital Humano.
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofCritical Reviews in Biotechnology, vol. , p. 1-18
dc.rightsrestrictedAccess
dc.subjectBacteria
dc.subjectBiotechnology
dc.subjectChemical compounds
dc.subjectEnzymes
dc.subjectHalogenation
dc.subjectMedical imaging
dc.subjectSynthesis (chemical)
dc.subject4-fluorothreonine
dc.subjectDichapetalum
dc.subjectFluorinase
dc.subjectFluorinated compound
dc.subjectFluorinated fatty acids
dc.subjectFluoroacetate
dc.subjectnucleocidin
dc.subjectS-adenosylmethionine
dc.subjectStreptomyces calvum
dc.subjectStreptomyces cattleya
dc.subjectFatty acids
dc.titleNatural production of fluorinated compounds and biotechnological prospects of the fluorinase enzyme
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoCIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
dc.identifier.doi10.1080/07388551.2016.1267109
dc.relation.publisherversionhttp://dx.doi.org/10.1080/07388551.2016.1267109
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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