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Author(s): Carvalhal F.
Correia-da-Silva M.
Sousa E.
Pinto M.
Kijjoa A.
Title: Sources and biological activities of marine sulfated steroids
Publisher: BioScientifica
Issue Date: 2018
Abstract: Marine environment is rich in structurally unique molecules and can be an inspiring source of novel drugs. Currently, six marine-derived drugs are in the market with FDA approval and several more are in the clinical pipeline. Structurally diverse and complex secondary metabolites have been isolated from the marine world and these include sulfated steroids. Biological activities of nearly 150 marine sulfated steroids reported from 1978 to 2017 are compiled and described, namely antimicrobial, antitumor, cardiovascular and antifouling activities. Structure–activity relationship for each activity is discussed. © 2018 Society for Endocrinology.
Subject: antibiotic agent
antifouling agent
antifungal agent
antiinflammatory agent
antineoplastic agent
antiparasitic agent
antithrombocytic agent
antivirus agent
beta secretase 1
cardiovascular agent
farnesoid X receptor
guanosine diphosphate
matrix metalloproteinase 14
pregnane X receptor
protein kinase C delta
protein kinase C inhibitor
protein tyrosine kinase
protein tyrosine kinase inhibitor
antibacterial activity
antifungal activity
antihypertensive activity
antiinflammatory activity
antineoplastic activity
antiproliferative activity
antiviral activity
biological activity
clinical trial
marine environment
microtubule assembly
priority journal
structure activity relation
Source: Journal of Molecular Endocrinology, vol. 61(2), p. T211-T231
Related Information: info:eu-repo/grantAgreement/FCT/5876/147268/PT
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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