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https://hdl.handle.net/10216/120300| Author(s): | Carvalhal F. Correia-da-Silva M. Sousa E. Pinto M. Kijjoa A. |
| Title: | Sources and biological activities of marine sulfated steroids |
| Publisher: | BioScientifica |
| Issue Date: | 2018 |
| Abstract: | Marine environment is rich in structurally unique molecules and can be an inspiring source of novel drugs. Currently, six marine-derived drugs are in the market with FDA approval and several more are in the clinical pipeline. Structurally diverse and complex secondary metabolites have been isolated from the marine world and these include sulfated steroids. Biological activities of nearly 150 marine sulfated steroids reported from 1978 to 2017 are compiled and described, namely antimicrobial, antitumor, cardiovascular and antifouling activities. Structure–activity relationship for each activity is discussed. © 2018 Society for Endocrinology. |
| Subject: | antibiotic agent antifouling agent antifungal agent antiinflammatory agent antineoplastic agent antiparasitic agent antithrombocytic agent antivirus agent beta secretase 1 cardiovascular agent farnesoid X receptor guanosine diphosphate matrix metalloproteinase 14 pregnane X receptor protein kinase C delta protein kinase C inhibitor protein tyrosine kinase protein tyrosine kinase inhibitor steroid angiogenesis antibacterial activity antifungal activity antihypertensive activity antiinflammatory activity antineoplastic activity antiproliferative activity antiviral activity apoptosis biological activity clinical trial hemolysis human marine environment microtubule assembly nonhuman osteoblast priority journal Review structure activity relation |
| DOI: | 10.1530/JME-17-0252 |
| URI: | https://hdl.handle.net/10216/120300 |
| Source: | Journal of Molecular Endocrinology, vol. 61(2), p. T211-T231 |
| Related Information: | info:eu-repo/grantAgreement/FCT/5876/147268/PT |
| Document Type: | Artigo em Revista Científica Internacional |
| Rights: | restrictedAccess |
| Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Carvalhal F_2018.pdf Restricted Access | 977.35 kB | Adobe PDF | View/Open |
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