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Author(s): Bessa L.J.
Buttachon S.
Dethoup T.
Martins R.
Vasconcelos V.
Kijjoa A.
da Costa P.M.
Title: Neofiscalin A and fiscalin C are potential novel indole alkaloid alternatives for the treatment of multidrugresistant Gram-positive bacterial infections
Publisher: Oxford University Press
Issue Date: 2016
Abstract: Ten indole alkaloids were obtained from the marine sponge-associated fungus Neosartorya siamensis KUFA 0017. We studied the antimicrobial properties of these and of three other compounds previously isolated from the soil fungus N. siamensis KUFC 6349. Only neofiscalin A showed antimicrobial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE); with a minimum inhibitory concentration (MIC) of 8 μg mL-1 against both strains. Another compound, fiscalin C, presented synergistic activity against MRSA when combined with oxacillin, although alone showed no antibacterial effect. Moreover, neofiscalin A, when present at sub-MICs, hampered the ability of both MRSA and VRE strains to form a biofilm. Additionally, the biofilm inhibitory concentration values of neofiscalin A against the MRSA and VRE isolates were 96 and 80 μg mL-1, respectively. At a concentration of 200 μg mL-1, neofiscalin A was able to reduce the metabolic activity of the biofilms by ~50%. One important fact is that our results also showed that neofiscalin A had no cytotoxicity against a human brain capillary endothelial cell line. © FEMS 2016.
Subject: antiinfective agent
fiscalin C
indole derivative
neofiscalin A
unclassified drug
antibacterial activity
antimicrobial activity
bacterial metabolism
brain capillary endothelial cell
controlled study
drug cytotoxicity
drug potentiation
Enterococcus faecalis
fungus isolation
Gram positive infection
human cell
methicillin resistant Staphylococcus aureus
minimum inhibitory concentration
multidrug resistance
Neosartorya siamensis
priority journal
sponge (Porifera)
vancomycin resistant Enterococcus
Source: FEMS Microbiology Letters, vol. 363(15)
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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