Please use this identifier to cite or link to this item:
da Costa P.M.
|Title:||Neofiscalin A and fiscalin C are potential novel indole alkaloid alternatives for the treatment of multidrugresistant Gram-positive bacterial infections|
|Publisher:||Oxford University Press|
|Abstract:||Ten indole alkaloids were obtained from the marine sponge-associated fungus Neosartorya siamensis KUFA 0017. We studied the antimicrobial properties of these and of three other compounds previously isolated from the soil fungus N. siamensis KUFC 6349. Only neofiscalin A showed antimicrobial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE); with a minimum inhibitory concentration (MIC) of 8 μg mL-1 against both strains. Another compound, fiscalin C, presented synergistic activity against MRSA when combined with oxacillin, although alone showed no antibacterial effect. Moreover, neofiscalin A, when present at sub-MICs, hampered the ability of both MRSA and VRE strains to form a biofilm. Additionally, the biofilm inhibitory concentration values of neofiscalin A against the MRSA and VRE isolates were 96 and 80 μg mL-1, respectively. At a concentration of 200 μg mL-1, neofiscalin A was able to reduce the metabolic activity of the biofilms by ~50%. One important fact is that our results also showed that neofiscalin A had no cytotoxicity against a human brain capillary endothelial cell line. © FEMS 2016.|
brain capillary endothelial cell
Gram positive infection
methicillin resistant Staphylococcus aureus
minimum inhibitory concentration
vancomycin resistant Enterococcus
|Source:||FEMS Microbiology Letters, vol. 363(15)|
|Document Type:||Artigo em Revista Científica Internacional|
|Appears in Collections:||CIIMAR - Artigo em Revista Científica Internacional|
Files in This Item:
|1.08 MB||Adobe PDF||Request a copy|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.