Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120275
Author(s): Buttachon S.
Ramos A.A.
Inácio Â.
Dethoup T.
Gales L.
Lee M.
Costa P.M.
Silva A.M.S.
Sekeroglu N.
Rocha E.
Pinto M.M.M.
Pereira J.A.
Kijjoa A.
Title: Bis-indolyl benzenoids, hydroxypyrrolidine derivatives and other constituents from cultures of the marine sponge-associated fungus aspergillus candidus KUFA0062
Publisher: MDPI
Issue Date: 2018
Abstract: A previously unreported bis-indolyl benzenoid, candidusin D (2e) and a new hydroxypyrrolidine alkaloid, preussin C (5b) were isolated together with fourteen previously described compounds: palmitic acid, clionasterol, ergosterol 5,8-endoperoxides, chrysophanic acid (1a), emodin (1b), six bis-indolyl benzenoids including asterriquinol D dimethyl ether (2a), petromurin C (2b), kumbicin B (2c), kumbicin A (2d), 2”-oxoasterriquinol D methyl ether (3), kumbicin D (4), the hydroxypyrrolidine alkaloid preussin (5a), (3S, 6S)-3,6-dibenzylpiperazine-2,5-dione (6) and 4-(acetylamino) benzoic acid (7), from the cultures of the marine sponge-associated fungus Aspergillus candidus KUFA 0062. Compounds 1a, 2a–e, 3, 4, 5a–b, and 6 were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. Only 5a exhibited an inhibitory effect against S. aureus ATCC 29213 and E. faecalis ATCC29212 as well as both methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE) strains. Both 1a and 5a also reduced significant biofilm formation in E. coli ATCC 25922. Moreover, 2b and 5a revealed a synergistic effect with oxacillin against MRSA S. aureus 66/1 while 5a exhibited a strong synergistic effect with the antibiotic colistin against E. coli 1410/1. Compound 1a, 2a–e, 3, 4, 5a–b, and 6 were also tested, together with the crude extract, for cytotoxic effect against eight cancer cell lines: HepG2, HT29, HCT116, A549, A 375, MCF-7, U-251, and T98G. Except for 1a, 2a, 2d, 4, and 6, all the compounds showed cytotoxicity against all the cancer cell lines tested. © 2018 by the authors
Subject: 2'' oxoasterriquinol D methyl ether
3,6 dibenzylpiperazine 2,5 dione
4 (acetylamino)benzoic acid
antibiotic agent
asterriquinol D dimethyl ether
benzene derivative
benzoic acid
bis indolyl benzenoid
candidusin D
chrysophanic acid
colistin
doxorubicin
fungal extract
kumbicin A
kumbicin B
kumbicin D
oxacillin
petromurin C
preussin
preussin C
pyrrolidine derivative
unclassified drug
vancomycin
anisomycin
antiinfective agent
antineoplastic agent
preussin
pyrrolidine derivative
terphenyl derivative
A-375 cell line
A-549 cell line
antibacterial activity
antineoplastic activity
Article
Aspergillus candidus
Aspergillus candidus KUFA 0062
biofilm
cell viability
controlled study
drug cytotoxicity
drug identification
drug isolation
drug potentiation
Enterococcus faecalis
Escherichia coli
fungal strain
fungus culture
HCT 116 cell line
Hep-G2 cell line
HT-29 cell line
human
human cell
IC50
in vitro study
MCF-7 cell line
methicillin resistant Staphylococcus aureus
minimum bactericidal concentration
minimum inhibitory concentration
nonhuman
Pseudomonas aeruginosa
Staphylococcus aureus
T98G cell line
U-251MG cell line
vancomycin resistant Enterococcus
analogs and derivatives
animal
antibiotic resistance
Aspergillus
bacterium
chemistry
drug effect
isolation and purification
microbial sensitivity test
microbiology
sponge (Porifera)
tumor cell line
Animals
Anisomycin
Anti-Bacterial Agents
Antineoplastic Agents
Aspergillus
Bacteria
Cell Line, Tumor
Drug Resistance, Bacterial
Drug Synergism
Humans
Inhibitory Concentration 50
Microbial Sensitivity Tests
Porifera
Pyrrolidines
Terphenyl Compounds
URI: https://hdl.handle.net/10216/120275
Source: Marine Drugs, vol. 16(4):119
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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