1. Repositório Aberto da Universidade do Porto
  2. CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
  3. CIIMAR - Artigo em Revista Científica Internacional
Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120272
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dc.creatorAndré A.
dc.creatorRuivo R.
dc.creatorCapitão A.
dc.creatorFroufe E.
dc.creatorPáscoa I.
dc.creatorCosta Castro L.F.
dc.creatorSantos M.M.
dc.date.accessioned2019-05-31T16:14:21Z-
dc.date.available2019-05-31T16:14:21Z-
dc.date.issued2017
dc.identifier.issn456535
dc.identifier.urihttps://hdl.handle.net/10216/120272-
dc.description.abstractIn the present work we provide the first isolation and functional characterization of a RXR orthologue in an annelid species, the Platynereis dumerilii. Using an in vitro luciferase reporter assay we evaluated the annelid receptor ability to respond to ligand 9-cis-retinoic acid, TBT and TPT. Our results show that the annelid RXR responds to 9-cis-retinoic acid and to the organotins by activating reporter gene transcription. The findings suggest a conserved mode of action of the receptor in response to a common signaling molecule and modulation by organotin compounds between vertebrates and Lophotrochozoans. © 2017 Elsevier
dc.description.sponsorshipThis work was supported by the Funda??o para a Ci?ncia e a Tecnologia (FCT) projects (PTDC/MAR/105199/2008 and EXPL/MAR/EST/1540/2012) and by Norte 2020 and FEDER (Coral - Sustainable Ocean Exploitation - Norte-01-0145-FEDER-000036). A Postdoctoral grant awarded to Raquel Ruivo (SFRH/BPD/72519/2010), a Research Technician grant awarded to In?s P?scoa (EXPL/MAR/EST/1540/2012/BTI/2013/015), and a PhD grant awarded to Ana Andr? (SFRH/BD/81243/2011) and to Ana Capit?o (SFRH/BD/90664/2012).
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofChemosphere, vol. 182, p. 753-761
dc.rightsrestrictedAccess
dc.subjectOrganometallics
dc.subjectAnnelid
dc.subjectEndocrine disruption
dc.subjectEvolution
dc.subjectRetinoid X receptor
dc.subjectTributyltin
dc.subjectTriphenyltin
dc.subjectTranscription
dc.subjectretinoic acid
dc.subjectretinoid X receptor
dc.subjectalitretinoin
dc.subjectligand
dc.subjectorganotin compound
dc.subjectretinoid X receptor
dc.subjectactivation energy
dc.subjectannelid
dc.subjectbioassay
dc.subjectendocrine disruptor
dc.subjectevolution
dc.subjectgenetic analysis
dc.subjectlaboratory method
dc.subjectligand
dc.subjectorganic acid
dc.subjecttoxicology
dc.subjectArticle
dc.subjectin vitro study
dc.subjectluciferase assay
dc.subjectmolecular cloning
dc.subjectnonhuman
dc.subjectPlatynereis dumerilii
dc.subjectPolychaeta
dc.subjectreporter gene
dc.subjectanimal
dc.subjectdrug effects
dc.subjectevolution
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectphysiology
dc.subjectPolychaeta
dc.subjecttranscription initiation
dc.subjectAnnelida
dc.subjectLophotrochozoa
dc.subjectPlatynereis dumerilii
dc.subjectVertebrata
dc.subjectAnimals
dc.subjectBiological Evolution
dc.subjectGene Expression Regulation
dc.subjectLigands
dc.subjectOrganotin Compounds
dc.subjectPolychaeta
dc.subjectRetinoid X Receptors
dc.subjectTranscriptional Activation
dc.subjectTretinoin
dc.titleCloning and functional characterization of a retinoid X receptor orthologue in Platynereis dumerilii: An evolutionary and toxicological perspective
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoCIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
dc.identifier.doi10.1016/j.chemosphere.2017.05.064
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.chemosphere.2017.05.064
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