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https://hdl.handle.net/10216/118195
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DC Field | Value | Language |
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dc.creator | Mesquita, I | |
dc.creator | Moreira, D | |
dc.creator | Sampaio-Marques, B | |
dc.creator | Laforge, M | |
dc.creator | Cordeiro-da-Silva, A | |
dc.creator | Ludovico, P | |
dc.creator | Estaquier, J | |
dc.creator | Silvestre, R | |
dc.date.accessioned | 2019-01-08T09:55:07Z | - |
dc.date.available | 2019-01-08T09:55:07Z | - |
dc.date.issued | 2016 | |
dc.identifier.issn | 1664-431X | |
dc.identifier.uri | https://repositorio-aberto.up.pt/handle/10216/118195 | - |
dc.description.abstract | During host-pathogen interactions, a complex web of events is crucial for the outcome of infection. Pathogen recognition triggers powerful cellular signaling events that is translated into the induction and maintenance of innate and adaptive host immunity against infection. In opposition, pathogens employ active mechanisms to manipulate host cell regulatory pathways toward their proliferation and survival. Among these, subversion of host cell energy metabolism by pathogens is currently recognized to play an important role in microbial growth and persistence. Extensive studies have documented the role of AMP-activated protein kinase (AMPK) signaling, a central cellular hub involved in the regulation of energy homeostasis, in host-pathogen interactions. Here, we highlight the most recent advances detailing how pathogens hijack cellular metabolism by suppressing or increasing the activity of the host energy sensor AMPK. We also address the role of lower eukaryote AMPK orthologues in the adaptive process to the host microenvironment and their contribution for pathogen survival, differentiation, and growth. Finally, we review the effects of pharmacological or genetic AMPK modulation on pathogen growth and persistence. | |
dc.description.sponsorship | This work was supported by grants to JE from the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) and from The Canadian HIV Cure Enterprise Team Grant HIG-13305 from the Canadian Institutes of Health Research (CIHR) in partnership with CANFAR and IAS. JE acknowledges the support of the Canada Research Chair I. Mesquita et al. program. It was also supported by FCT—Fundação para a Ciência e a Tecnologia/MEC — Ministério da Educação e Ciência através de fundos nacionais e quando aplicável cofinanciado pelo FEDER, no âmbito do Acordo de Parceria PT2020 referente à unidade de investigação nº 4293. DMis supported by SFRH/BD/91543/2012. RS is supported by the Fundação para a Ciência e Tecnologia (FCT) (IF/00021/2014). | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F91543%2F2012/PT | |
dc.relation.ispartof | Experientia Supplementum, vol.107, p. 287-323 | |
dc.rights | openAccess | |
dc.subject.mesh | AMP-Activated Protein Kinases/antagonists & inhibitors | |
dc.subject.mesh | AMP-Activated Protein Kinases/genetics | |
dc.subject.mesh | AMP-Activated Protein Kinases/immunology | |
dc.subject.mesh | Anti-Infective Agents/therapeutic use | |
dc.subject.mesh | Autophagy/drug effects | |
dc.subject.mesh | Autophagy/immunology | |
dc.subject.mesh | Bacteria/drug effects | |
dc.subject.mesh | Bacteria/genetics | |
dc.subject.mesh | Bacteria/metabolism | |
dc.subject.mesh | Bacterial Infections/drug therapy | |
dc.subject.mesh | Bacterial Infections/enzymology | |
dc.subject.mesh | Bacterial Infections/genetics | |
dc.subject.mesh | Bacterial Infections/virology | |
dc.subject.mesh | Fungi/drug effects | |
dc.subject.mesh | Fungi/enzymology | |
dc.subject.mesh | Fungi/genetics | |
dc.subject.mesh | Gene Expression Regulation | |
dc.subject.mesh | Host-Pathogen Interactions/drug effects | |
dc.subject.mesh | Host-Pathogen Interactions/genetics | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Immunity, Innate/drug effects | |
dc.subject.mesh | Molecular Targeted Therapy | |
dc.subject.mesh | Mycoses/drug therapy | |
dc.subject.mesh | Mycoses/enzymology | |
dc.subject.mesh | Mycoses/genetics | |
dc.subject.mesh | Mycoses/virology | |
dc.subject.mesh | Protein Subunits/antagonists & inhibitors | |
dc.subject.mesh | Protein Subunits/genetics | |
dc.subject.mesh | Protein Subunits/immunology | |
dc.subject.mesh | Protein-Serine-Threonine Kinases/antagonists & inhibitors | |
dc.subject.mesh | Protein-Serine-Threonine Kinases/genetics | |
dc.subject.mesh | Protein-Serine-Threonine Kinases/immunology | |
dc.subject.mesh | Signal Transduction | |
dc.subject.mesh | Virus Diseases/drug therapy | |
dc.subject.mesh | Virus Diseases/enzymology | |
dc.subject.mesh | Virus Diseases/genetics | |
dc.subject.mesh | Virus Diseases/virology | |
dc.subject.mesh | Viruses/drug effects | |
dc.subject.mesh | Viruses/genetics | |
dc.subject.mesh | Viruses/metabolism | |
dc.title | AMPK in Pathogens | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Instituto de Investigação e Inovação em Saúde | |
dc.identifier.doi | 10.1007/978-3-319-43589-3_12 | |
dc.relation.publisherversion | https://link.springer.com/chapter/10.1007%2F978-3-319-43589-3_12 | |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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Mesquita2016.pdf | 817.78 kB | Adobe PDF | View/Open |
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