Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/115740
Author(s): | Sílvia Castro Coelho Daniel Pires Reis Maria do Carmo Pereira Manuel A. N. Coelho |
Title: | Gold nanoparticles for targeting varlitinib to human pancreatic cancer cells |
Issue Date: | 2018 |
Abstract: | Colloidal gold nanoparticles are targeting probes to improve varlitinib delivery into cancer cells. The nanoconjugates were designed by the bioconjugation of pegylated gold nanoparticles with varlitinib via carbodiimide-mediated cross-linking and characterized by infrared and X-ray photoelectron spectroscopy. The drug release response shows an initial delay and a complete drug release after 72 h is detected. In vitro experiments with MIA PaCa-2 cells corroborate that PEGAuNPsVarl conjugates increase the varlitinib toxic effect at very low concentrations (IC50 = 80 nM) if compared with varlitinib alone (IC50 = 259 nM). Our results acknowledge a decrease of drug side effects in normal cells and an enhancement of drug efficacy against to the pancreatic cancer cells reported. (c) 2018 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://hdl.handle.net/10216/115740 |
Related Information: | info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projectos de Cooperação Internacional/TRANSCAN/0001/2012/Nanoparticle enhanced molecular Fluorescence-Endoscopy for detection of early stage colorectal adenocarcinoma/NanoEFEct |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
Appears in Collections: | FEUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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283584.pdf | 2.32 MB | Adobe PDF | View/Open |
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