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https://hdl.handle.net/10216/115698
Full metadata record
DC Field | Value | Language |
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dc.creator | Maria João Ramalho | |
dc.creator | E. Sevin | |
dc.creator | F. Gosselet | |
dc.creator | J. Lima | |
dc.creator | Manuel A. Coelho | |
dc.creator | Joana A. Loureiro | |
dc.creator | Maria do Carmo Pereira | |
dc.date.accessioned | 2022-09-11T18:01:03Z | - |
dc.date.available | 2022-09-11T18:01:03Z | - |
dc.date.issued | 2018 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.other | sigarra:288084 | |
dc.identifier.uri | https://hdl.handle.net/10216/115698 | - |
dc.description.abstract | Glioblastoma multiforme is the most lethal type of brain tumor and the established therapy only extends patients survival to approximately one year. Its first-line treatment is based on of chemotherapy with the alkylating agent temozolomide (TMZ). As many other chemotherapeutic drugs, TMZ presents several limitations as high toxicity and low bioavailability. The delivery of TMZ using poly(lactic-co-glycolic acid) nanoparticles is proposed in this work. Stable nanoparticles functionalized with a OX26 type monoclonal antibody for transferrin receptor were developed, targeting the glioblastoma tumor cells, since these cells are known for overexpressing this receptor. The release profile of TMZ from the nanoparticles was studied mimicking physiological conditions, and targeted cellular internalization was also investigated. Two glioblastoma cell lines - U215 and U87 - were used to evaluate the in vitro cytotoxicity of the drug, showing that the prepared nanocarriers enhance the anticancer activity of TMZ. The functionalization with the monoclonal antibody for transferrin receptor proved to be advantageous in enhancing the cellular internalization in glioblastoma cells. | |
dc.language.iso | eng | |
dc.relation | info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE | |
dc.relation | info:eu-repo/grantAgreement/Comissão de Coordenação e Desenvolvimento Regional do Norte/P2020|Norte2020-Projetos Integrados ICDT/NORTE-01-0145-FEDER-000005/LEPABE-2-ECO-INNOVATION/LEPABE-2-ECO-INNOVATION | |
dc.relation | info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de Cooperação Internacional/TRANSCAN/0001/2012/Nanoparticle enhanced molecular Fluorescence-Endoscopy for detection of early stage colorectal adenocarcinoma/NanoEFEct | |
dc.rights | restrictedAccess | |
dc.title | Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Faculdade de Engenharia | |
dc.identifier.doi | 10.1016/j.ijpharm.2018.04.062 | |
dc.identifier.authenticus | P-00Q-HJY | |
Appears in Collections: | FEUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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288084.pdf Restricted Access | 1.49 MB | Adobe PDF | Request a copy from the Author(s) |
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