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Author(s): Mónica S. F. Santos
Helena Franquet-Griell
Arminda Alves
Silvia Lacorte
Title: Development of an analytical methodology for the analysis of priority cytostatics in water
Issue Date: 2018-07
Abstract: The consumption of cytostatics has remarkably increased over the last years due to the high cancer incidenceworldwide. In previous studies, seven cytostatics were already recognized to potentially induce chronic effectsin aquatic organisms, taking into account their estimated concentrations in surface waters: cyclophosphamide(CYC), capecitabine (CAP), mycophenolic acid (MPA), imatinib (IMA), bicalutamide (BICA), prednisone (PRED)and 5-fluorouracil (5FU). The objective of the present study was to simultaneously analyse these 7 prioritizedcompounds, which have the highest chances to be found in surface and wastewaters. The analytical challenge reliesin the determination of these very polar compounds, which have different chemical and structural properties.Solid-phase extraction with an Ultra Performance Liquid Chromatograph-Mass Spectrometer in electrospray ionizationmixed mode (5-fluorouracil and bicalutamide in negative mode and the others in positive one) was developedto determine seven cytostatics in wastewater and surface water. Among eight tested cartridges withdifferent sorbents and conditions, the best extraction performance was attained with Oasis WAX at pH 10,with recoveries ranging from 31 ± 4 (5FU) and 103 ± 17% (MPA). Regarding the chromatographic analysis,the best results were achieved with an XBridge amide column. The final analytical methodology was successfullyapplied for the analysis of real water samples, confirming the presence of risky cytostatics in surface andwastewaters.
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE
info:eu-repo/grantAgreement/Comissão de Coordenação e Desenvolvimento Regional do Norte/P2020|Norte2020-Projetos Integrados ICDT/NORTE-01-0145-FEDER-000005/LEPABE-2-ECO-INNOVATION/LEPABE-2-ECO-INNOVATION
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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