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https://hdl.handle.net/10216/114764
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DC Field | Value | Language |
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dc.creator | Brandão, M | |
dc.creator | Lopes, C | |
dc.creator | Ramos, E | |
dc.date.accessioned | 2018-08-27T11:34:56Z | - |
dc.date.available | 2018-08-27T11:34:56Z | - |
dc.date.issued | 2013 | |
dc.identifier.issn | 0091-7435 | |
dc.identifier.uri | http://hdl.handle.net/10216/114764 | - |
dc.description.abstract | Objective: To evaluate the role of adding grandparents' data to parental information to the assessment of a family history of diabetes, in order to identify adolescents with high fasting glucose. Method: In 2003 we evaluated 1276 population-based 13-year-olds, from Porto, Portugal. The history of diabetes in parents and grandparents was collected using self-reported questionnaires and a clinical evaluation was performed, including a fasting blood sample. The 75th percentile of fasting plasma glucose (FPG = 91 mg/dl) was used to create two groups of participants (high vs. low fasting glucose). Results: No association was found between family history of diabetes (with or without grandparental data) and a high FPG. The sensitivity to identify individuals with high FPG increased from 7.8% to 47.9% when grandparental history was combined with parental data. The positive predictive value was slightly increased (25.2% vs. 27.8%) but the specificity dropped (91.8% vs. 56.4%). Conclusion: Combining parental with grandparental history increased the number of adolescents with a positive family history of diabetes and also increased the sensitivity to identify adolescents with high FPG. So, even if it determines a decrease in specificity, grandparental data is relevant when screening for high fasting glucose in adolescents. | |
dc.language.iso | eng | |
dc.relation.ispartof | Prev Med, vol. 57(5), p. 500-504 | |
dc.rights | openAccess | |
dc.subject | Type 2 diabetes mellitus - Adolescent | |
dc.subject | Abnormal glycemia | |
dc.subject | Family history | |
dc.title | Identifying adolescents with high fasting glucose: the importance of adding grandparents' data when assessing family history of diabetes | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Instituto de Saúde Pública | |
dc.identifier.doi | 10.1016/j.ypmed.2013.06.028 | |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S009174351300220X?via%3Dihub | |
Appears in Collections: | ISPUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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BrandaoM2013.pdf | 218.47 kB | Adobe PDF | View/Open |
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