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Author(s): Günther, G
van Leth, F
Altet, N
Dedicoat, M
Duarte, R
Gualano, G
Kunst, H
Muylle, I
Spinu, V
Tiberi, S
Viiklepp, P
Lange, C
Title: Beyond multidrug-resistant tuberculosis in Europe: a TBNET study
Issue Date: 2015
Abstract: The emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe. We evaluated second-line drug susceptibility testing in Mycobacterium tuberculosis isolates from patients with multidrug-resistant, pre-extensively drug-resistant (pre-XDR-TB) and XDR-TB at 23 TBNET sites in 16 European countries. Over 30% of bacilli from patients with pre-XDR-TB showed resistance to any fluoroquinolone and almost 70% to any second-line injectable drug. Respectively >90% and >80% of the XDR-TB strains tested showed phenotypic resistance to pyrazinamide and ethambutol. Resistance to prothionamide/ethionamide was high in bacilli from pre-XDR-TB patients (43%) and XDR-TB patients (49%).
Subject: Multidrug-resistant tuberculosis
Source: Int J Tuberc Lung Dis, vol. 19(12), p. 1524-1527
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:ISPUP - Artigo em Revista Científica Internacional

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