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https://hdl.handle.net/10216/114669| Author(s): | Günther, G van Leth, F Altet, N Dedicoat, M Duarte, R Gualano, G Kunst, H Muylle, I Spinu, V Tiberi, S Viiklepp, P Lange, C |
| Title: | Beyond multidrug-resistant tuberculosis in Europe: a TBNET study |
| Issue Date: | 2015 |
| Abstract: | The emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe. We evaluated second-line drug susceptibility testing in Mycobacterium tuberculosis isolates from patients with multidrug-resistant, pre-extensively drug-resistant (pre-XDR-TB) and XDR-TB at 23 TBNET sites in 16 European countries. Over 30% of bacilli from patients with pre-XDR-TB showed resistance to any fluoroquinolone and almost 70% to any second-line injectable drug. Respectively >90% and >80% of the XDR-TB strains tested showed phenotypic resistance to pyrazinamide and ethambutol. Resistance to prothionamide/ethionamide was high in bacilli from pre-XDR-TB patients (43%) and XDR-TB patients (49%). |
| Subject: | Multidrug-resistant tuberculosis |
| DOI: | 10.5588/ijtld.15.0274 |
| URI: | http://hdl.handle.net/10216/114669 |
| Source: | Int J Tuberc Lung Dis, vol. 19(12), p. 1524-1527 |
| Document Type: | Artigo em Revista Científica Internacional |
| Rights: | openAccess |
| Appears in Collections: | ISPUP - Artigo em Revista Científica Internacional |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| GuntherGvanLethF2015.pdf | 74.03 kB | Adobe PDF |  View/Open |
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