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https://hdl.handle.net/10216/111764
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DC Field | Value | Language |
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dc.creator | Abubakar, I | - |
dc.creator | Morais, S | - |
dc.creator | Ferro, A | - |
dc.creator | Lunet, N | - |
dc.date.accessioned | 2018-04-30T12:35:39Z | - |
dc.date.available | 2018-04-30T12:35:39Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1590-8658 | - |
dc.identifier.uri | http://hdl.handle.net/10216/111764 | - |
dc.description.abstract | Background: The main outcome of Helicobacter pylori infection, i.e. gastric cancer, is more frequent in men, but there is no comprehensive synthesis of the evidence on a potential role of sex in the acquisition and/or persistence of infection. Aims: To quantify the association between sex and H. pylori infection in pediatric and adult populations, through systematic review and meta-analysis. Methods: PubMed® was searched, from inception to September 2015, to identify population-based studies reporting the prevalence and/or incidence of H. pylori infection in both sexes. Odds ratios (OR) or data to compute them were extracted; adjusted estimates were preferred, whenever available. The DerSimonian and Laird method was used to compute summary estimates and respective 95% confidence intervals (95%CI), separately for children and adults. Results: Among a total of 244 studies, mostly cross-sectional, male sex was associated with a greater prevalence of H. pylori infection, both in children (102 studies, OR = 1.06, 95%CI: 1.01, 1.12, I2 = 43.7%) and adults (169 studies, OR = 1.12, 95%CI: 1.09, 1.15, I2 = 68.5%). An underrepresentation of studies showing a negative association between male sex and infection was observed (Egger’s test: p = 0.006). Conclusions: Although further research is needed to understand the mechanisms by which sex may influence the acquisition and/or persistence of infection, our results support a small contribution of sex differences in the prevalence of infection to the male predominance of H. pylori-related outcomes, including gastric cancer. | pt_PT |
dc.description.sponsorship | This work was supported by “Fundo Europeu de Desenvolvimento Regional” (FEDER) funds through the “Programa Operacional Factores de Competitividade” (POFC)—COMPETE (FCOMP-01-0124-FEDER-021181) and by national funds through the “Fundação para a Ciência e a Tecnologia” (PTDC/SAU-EPI/122460/2010), and by the Epidemiology Research Unit—Institute of Public Health, University of Porto (POCI-01-0145-FEDER-006862; UID/DTP/047507/2013). Individual grants attributed to BP (SFRH/BPD/75918/2011 and SFRH/BPD/108751/2015), AF (PD/BD/105823/2014) and SM (SFRH/BD/102585/2014) were supported by “Fundação para a Ciência e a Tecnologia”, and the “Programa Operacional Potencial Humano” (POPH/FSE). | pt_PT |
dc.language.iso | eng | pt_PT |
dc.publisher | Elsevier | pt_PT |
dc.relation.ispartofseries | Dig Liver Dis, vol. 49(7), p. 742-749 | pt_PT |
dc.rights | openAccess | pt_PT |
dc.subject | Helicobacter pylori | pt_PT |
dc.title | Sex-differences in the prevalence of Helicobacter pylori infection in pediatric and adult populations: Systematic review and meta-analysis of 244 studies | pt_PT |
dc.type | Outra Publicação em Revista Científica Internacional | pt_PT |
dc.contributor.uporto | Instituto de Saúde Pública | pt_PT |
dc.identifier.doi | 10.1016/j.dld.2017.03.019 | - |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1590865817307995?via%3Dihub | - |
Appears in Collections: | ISPUP - Outra Publicação em Revista Científica Internacional |
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File | Description | Size | Format | |
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Ibrahim497.pdf | 2.13 MB | Adobe PDF | View/Open |
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