Please use this identifier to cite or link to this item:
Author(s): Sánchez-Flores, M
MArcos-Pérez, D
Costa, S
Teixeira, JP
Bonassi, S
Pásaro, E
Laffon, B
Valdiglesias, V
Title: Oxidative stress, genomic features and DNA repair in frail elderly: a systematic review
Publisher: Elsevier
Issue Date: 2017
Abstract: Frailty is an emerging geriatric syndrome characterized by higher vulnerability to stressors, with an increased risk of adverse health outcomes such as mortality, morbidity, disability, hospitalization, and institutionalization. Although it is generally recognized to have a biological basis, no particular biological trait has been consistently associated to frailty status so far. In this work, epidemiological studies evaluating association of frailty status with alterations at cellular level − namely oxidative stress, genomic instability and DNA damage and repair biomarkers −were revised and compared. A total of 25 studies fulfilled inclusion/exclusion criteria and, consequently, were included in the review. Variations of oxidative stress biomarkers were often associated to frailty status in older people. On the contrary, genomic instability seems not to be linked to frailty. The only study which addressed the possible relationship between DNA repair modulations and frailty status also failed in finding association. Despite the large number of cellular alterations known to be associated with frailty, studies on this issue are still very scarce and limited to some of the possible cellular targets. The established link between DNA repair, genomic instability, and age and age-related disorders, encourage deeper investigations on this line.
Subject: Cellular biomarkers
DNA - Repair
Oxidative stress
Genomic instability
Series: Ageing Res Ver, vol. 37, p. 1
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:ISPUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
Sanchez-Flores37.pdf1.1 MBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.