Please use this identifier to cite or link to this item:
Author(s): Lewis, KM
Ruiz, M
Goldblatt, P
Morrison, J
Porta, D
Forastiere, F
Hryhorczuk, D
Zvinchuk, O
Saurel-Cubizolles, MJ
Lioret, S
Annesi-Maesano, I
Vrijheid, M
Torrent, M
Iniguez, C
Larranaga, I
Ginkel, MWH
Vrijkotte, TGM
Klanova, J
Svancara, J
Barros, H
Correia, S
Jarvelin, MR
Taanila, A
Ludvigsson, J
Faresjo, T
Marmot, M
Pikhart, H
Title: Mother's education and offspring asthma risk in 10 European cohort studies
Publisher: Springer
Issue Date: 2017
Abstract: Highly prevalent and typically beginning in childhood, asthma is a burdensome disease, yet the risk factors for this condition are not clarified. To enhance understanding, this study assessed the cohort-specific and pooled risk of maternal education on asthma in children aged 3–8 across 10 European countries. Data on 47,099 children were obtained from prospective birth cohort studies across 10 European countries. We calculated cohort-specific prevalence difference in asthma outcomes using the relative index of inequality (RII) and slope index of inequality (SII). Results from all countries were pooled using random-effects meta-analysis procedures to obtain mean RII and SII scores at the European level. Final models were adjusted for child sex, smoking during pregnancy, parity, mother’s age and ethnicity. The higher the score the greater the magnitude of relative (RII, reference 1) and absolute (SII, reference 0) inequity. The pooled RII estimate for asthma risk across all cohorts was 1.46 (95% CI 1.26, 1.71) and the pooled SII estimate was 1.90 (95% CI 0.26, 3.54). Of the countries examined, France, the United Kingdom and the Netherlands had the highest prevalence’s of childhood asthma and the largest inequity in asthma risk. Smaller inverse associations were noted for all other countries except Italy, which presented contradictory scores, but with small effect sizes. Tests for heterogeneity yielded significant results for SII scores. Overall, offspring of mothers with a low level of education had an increased relative and absolute risk of asthma compared to offspring of high-educated mothers.
Subject: Maternal education
Asthma - Children
Series: Eur J Epidemiol, vol. 32(9), p. 797-805
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:ISPUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
Lewis32.pdf724.9 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.