Please use this identifier to cite or link to this item:
Author(s): Ramalho, M
Fontes, F
Ruano, L
Pereira, S
Lunet, N
Title: Cognitive impairment in the first year after breast cancer diagnosis: A prospective cohort study
Publisher: Elsevier
Issue Date: 2017
Abstract: Objectives: The objective of this study was to assess the relation between cancer treatments and incident cognitive impairment in breast cancer patients, taking into account the levels of anxiety before treatment. Materials and methods: We conducted a prospective cohort study with 418 newly diagnosed breast cancer patients with no cognitive impairment, defined as values at least 1.5 standard deviations below age- and education-adjusted cut-offs in the Montreal Cognitive Assessment (MoCA), at baseline. The Hospital Anxiety and Depression Scale and MoCA were used for evaluations before treatment and at 1-year after diagnosis. We used Poisson regressions to compute adjusted relative risks (RR) and corresponding 95% confidence intervals (95%CI) to identify predictors of cognitive impairment. Results: The median (Percentile 25, Percentile 75) MoCA score before treatment was 24 (21, 26). A total of 8.1% (95%CI: 5.8, 11.2) of the patients presented incident cognitive impairment during the follow-up. There was a statistically significant interaction between anxiety at baseline and the effect of chemotherapy on the incidence of cognitive impairment (P for interaction ¼ 0.028). There was a significantly increased risk of incident cognitive impairment among patients with no anxiety prior to treatment with schemes including doxorubicin and cyclophosphamide (adjusted RR ¼ 4.22, 95%CI: 1.22, 14.65). Conclusion: There was a statistically significant association between chemotherapy and cognitive impairment, but only among women with no anxiety at baseline.
Subject: Antineoplastic protocols
Breast cancer
Cognition disorders - Anxiety
Series: Breast, vol. 13(32), p. 173-178
Related Information: info:eu-repo/grantAgreement/FCT/5876/147349/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:ISPUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
Ramalho1332.pdf254.33 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.