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https://hdl.handle.net/10216/109577
Author(s): | Pereira, L Richards, M Goios, A Alonso, A Albarrán, C Garcia, O Behar, DM Gölge, M Hatina, J Al-Gazali, L Bradley, DG Macaulay, V Amorim, A |
Title: | Evaluating the forensic informativeness of mtDNA haplogroup H sub-typing on a Eurasian scale |
Publisher: | Elsevier Inc. |
Issue Date: | 2006 |
Abstract: | The impact of phylogeographic information on mtDNA forensics has been limited to the quality control of published sequences and databases. In this work we use the information already available on Eurasian mtDNA phylogeography to guide the choice of coding-region SNPs for haplogroup H. This sub-typing is particularly important in forensics since, even when sequencing both HVRI and HVRII, the discriminating power is low in some Eurasian populations. We show that a small set (eight) of coding-region SNPs resolves a substantial proportion of the identical haplotypes, as defined by control-region variation alone. Moreover, this SNP set, while substantially increasing the discriminating efficiency in most Eurasian populations by roughly equal amounts, discloses population-specific profiles. |
Subject: | Human mtDNA Haplogroup H Haplotype diversity HVRI and HVRII Coding-region SNPs Eurasia |
URI: | http://hdl.handle.net/10216/109577 |
Source: | Forensic Science International, vol. 159(1), p. 43-50 |
Related Information: | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F16518%2F2004/PT info:eu-repo/grantAgreement/FCT/POCI/45139/PT |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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Pereira2006FSI.pdf Restricted Access | 385.46 kB | Adobe PDF | Request a copy | |
Pereira2006FSISuppMaterial.doc Restricted Access | 377.5 kB | Microsoft Word | Request a copy |
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