1. Repositório Aberto da Universidade do Porto
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  3. I3S - Artigo em Revista Científica Internacional
Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/109570
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dc.creatorPereira, L
dc.creatorGonçalves, J
dc.creatorFranco-Duarte, R
dc.creatorSilva, J
dc.creatorRocha, T
dc.creatorArnold, C
dc.creatorRichards, M
dc.creatorMacaulay, V
dc.date.accessioned2017-12-21T17:04:51Z-
dc.date.available2017-12-21T17:04:51Z-
dc.date.issued2007
dc.identifier.issn0737-4038
dc.identifier.urihttp://hdl.handle.net/10216/109570-
dc.description.abstractThe first complete mitochondrial DNA (mtDNA) sequences (approximately 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.
dc.description.sponsorshipThis work was partially supported by Fundação para a Ciência e a Tecnologia—Programa de Financiamento Plirianual do Centro de Investigação de Genética Molecular Humana and by Research Project POCTI/SAU/97/2001 from Fundação para a Ciência e a Tecnologia.
dc.language.isoeng
dc.publisherOxford University Press
dc.relationinfo:eu-repo/grantAgreement/FCT/POCI/930/PT
dc.relation.ispartofMolecular Biology and Evolution, vol. 24(3), p. 868-74
dc.rightsrestrictedAccess
dc.subjectmtDNA
dc.subjectComplete sequences
dc.subjectAsthenozoospermia
dc.subjectAssociation
dc.titleNo evidence for an mtDNA role in sperm motility: data from complete sequencing of asthenozoospermic males
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoInstituto de Investigação e Inovação em Saúde
dc.identifier.doi10.1093/molbev/msm004
dc.relation.publisherversionhttps://academic.oup.com/mbe/article/24/3/868/1247055
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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