Please use this identifier to cite or link to this item: http://hdl.handle.net/10216/109561
Author(s): Costa, MD
Fernandes, V
Freitas, F
Cherni, L
El Gaaied, ABA
Pereira, L
Title: Data from complete mtDNA sequencing of Tunisian centenarians: testing haplogroup association and the "golden mean" to longevity
Publisher: Elsevier Inc.
Issue Date: 2009
Abstract: Since the mitochondrial theory of ageing was proposed, mitochondrial DNA (mtDNA) diversity has been largely studied in old people, however complete genomes are still rare, being limited to Japanese and UK/US samples. In this work, we evaluated possible longevity associated polymorphisms/haplogroups in an African population, from Tunisia, by performing complete mtDNA sequencing. This population has a mixed Eurasian/sub-Saharan mtDNA gene pool, which could potentially facilitate the evaluation of association for sub-Saharan lineages. Sub-Saharan haplogroups were shown to be significantly less represented in centenarians (9.5%) than in controls (54.5%), but it is not possible to rule out an influence of population structure, which is high in these populations. No recurrent polymorphism were more frequent in centenarians than in controls, and although the Tunisian centenarians presented less synonymous and replacement polymorphisms than controls, this difference was not statistically significant. So far, it does not seem that centenarians have significantly less mildly deleterious substitutions, not only in Tunisia but also in Japanese and UK/US samples, as tested here, not favouring a "golden mean" to longevity.
Subject: mtDNA
Complete sequencing
Centenarians
Tunisia
URI: http://hdl.handle.net/10216/109561
Source: Mechanisms of Ageing and Development, vol. 130(4), p. 222-6
Related Information: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/71422/PT
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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