Please use this identifier to cite or link to this item: http://hdl.handle.net/10216/109545
Author(s): Fernandes, V
Alshamali, F
Alves, M
Costa, MD
Pereira, JB
Silva, NM
Cherni, L
Harich, N
Cerny, V
Soares, P
Richards, MB
Pereira, L
Title: The Arabian cradle: Mitochondrial relicts of the first steps along the southern route out of Africa
Publisher: Elsevier Inc.
Issue Date: 2012
Abstract: A major unanswered question regarding the dispersal of modern humans around the world concerns the geographical site of the first human steps outside of Africa. The "southern coastal route" model predicts that the early stages of the dispersal took place when people crossed the Red Sea to southern Arabia, but genetic evidence has hitherto been tenuous. We have addressed this question by analyzing the three minor west-Eurasian haplogroups, N1, N2, and X. These lineages branch directly from the first non-African founder node, the root of haplogroup N, and coalesce to the time of the first successful movement of modern humans out of Africa, ∼60 thousand years (ka) ago. We sequenced complete mtDNA genomes from 85 Southwest Asian samples carrying these haplogroups and compared them with a database of 300 European examples. The results show that these minor haplogroups have a relict distribution that suggests an ancient ancestry within the Arabian Peninsula, and they most likely spread from the Gulf Oasis region toward the Near East and Europe during the pluvial period 55-24 ka ago. This pattern suggests that Arabia was indeed the first staging post in the spread of modern humans around the world.
Subject: Africa
African Continental Ancestry Group/genetics
Arabia
Asian Continental Ancestry Group/genetics
DNA Mitochondrial/genetics
Databases Genetic
Emigration and Immigration
Ethnic Groups/genetics
European Continental Ancestry Group/genetics
Evolution Molecular
Genetic Variation/genetics
Genetics Population/methods
Geography
Haplotypes/genetics
Humans
Middle East
Mitochondria/genetics
Molecular Sequence Data
Phylogeny
URI: http://hdl.handle.net/10216/109545
Source: American Journal of Human Genetics, vol. 90(2), p. 347-55
Related Information: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/113832/PT
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F61342%2F2009/PT
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F69119%2F2010/PT
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F45657%2F2008/PT
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F48372%2F2008/PT
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F64233%2F2009/PT
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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