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Author(s): Pereira, L
Richards, M
Goios, A
Alonso, A
Albarrán, C
Garcia, O
Behar, DM
Gölge, M
Hatina, J
Al-Gazali, L
Bradley, DG
Macaulay, V
Amorim, A
Title: High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
Publisher: Cold Spring Harbor Laboratory Press
Issue Date: 2005
Abstract: The advent of complete mitochondrial DNA (mtDNA) sequence data has ushered in a new phase of human evolutionary studies. Even quite limited volumes of complete mtDNA sequence data can now be used to identify the critical polymorphisms that define sub-clades within an mtDNA haplogroup, providing a springboard for large-scale high-resolution screening of human mtDNAs. This strategy has in the past been applied to mtDNA haplogroup V, which represents <5% of European mtDNAs. Here we adopted a similar approach to haplogroup H, by far the most common European haplogroup, which at lower resolution displayed a rather uninformative frequency distribution within Europe. Using polymorphism information derived from the growing complete mtDNA sequence database, we sequenced 1580 base pairs of targeted coding-region segments of the mtDNA genome in 649 individuals harboring mtDNA haplogroup H from populations throughout Europe, the Caucasus, and the Near East. The enhanced genealogical resolution clearly shows that sub-clades of haplogroup H have highly distinctive geographical distributions. The patterns of frequency and diversity suggest that haplogroup H entered Europe from the Near East approximately 20,000-25,000 years ago, around the time of the Last Glacial Maximum (LGM), and some sub-clades re-expanded from an Iberian refugium when the glaciers retreated approximately 15,000 years ago. This shows that a large fraction of the maternal ancestry of modern Europeans traces back to the expansion of hunter-gatherer populations at the end of the last Ice Age.
Subject: DNA Mitochondrial/genetics
Electron Transport Complex IV/genetics
Emigration and Immigration
Evolution Molecular
Genetics Population/methods
Molecular Sequence Data
Source: Genome Research, vol. 15(1), p. 19-24
Related Information: info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F7121%2F2001/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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