Please use this identifier to cite or link to this item: http://hdl.handle.net/10216/109255
Author(s): Silva, NM
Pereira, L
Poloni, ES
Currat, M
Title: Human neutral genetic variation and forensic STR data
Publisher: Public Library of Science
Issue Date: 2012
Abstract: The forensic genetics field is generating extensive population data on polymorphism of short tandem repeats (STR) markers in globally distributed samples. In this study we explored and quantified the informative power of these datasets to address issues related to human evolution and diversity, by using two online resources: an allele frequency dataset representing 141 populations summing up to almost 26 thousand individuals; a genotype dataset consisting of 42 populations and more than 11 thousand individuals. We show that the genetic relationships between populations based on forensic STRs are best explained by geography, as observed when analysing other worldwide datasets generated specifically to study human diversity. However, the global level of genetic differentiation between populations (as measured by a fixation index) is about half the value estimated with those other datasets, which contain a much higher number of markers but much less individuals. We suggest that the main factor explaining this difference is an ascertainment bias in forensics data resulting from the choice of markers for individual identification. We show that this choice results in average low variance of heterozygosity across world regions, and hence in low differentiation among populations. Thus, the forensic genetic markers currently produced for the purpose of individual assignment and identification allow the detection of the patterns of neutral genetic structure that characterize the human population but they do underestimate the levels of this genetic structure compared to the datasets of STRs (or other kinds of markers) generated specifically to study the diversity of human populations.
Subject: Africa
Alleles
Databases Genetic
Evolution Molecular
Forensic Genetics/methods
Gene Frequency
Genetic Markers
Genetic Variation
Genetics Population
Geography
Humans
Microsatellite Repeats
Polymorphism Genetic
URI: http://hdl.handle.net/10216/109255
Source: PLoS One, vol. 7(11):e49666
Related Information: info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F69119%2F2010/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by/4.0/
Appears in Collections:I3S - Artigo em Revista Científica Internacional



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