Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/107522
Author(s): Elmano Pinto
Vera Faustino
Raquel O. Rodrigues
Diana Pinho
Valdemar Garcia
João M. Miranda
Rui Lima
Title: A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis
Issue Date: 2015
Abstract: Microfluidic devices are electrical/mechanical systems that offer the ability towork with minimal sample volumes, short reactions times, and have the possibility toperform massive parallel operations. An important application of microfluidics is bloodrheology in microdevices, which has played a key role in recent developments of lab-on-chipdevices for blood sampling and analysis. The most popular and traditional method tofabricate these types of devices is the polydimethylsiloxane (PDMS) soft lithographytechnique, which requires molds, usually produced by photolithography. Although theresearch results are extremely encouraging, the high costs and time involved in theproduction of molds by photolithography is currently slowing down the development cycleof these types of devices. Here we present a simple, rapid, and low-cost nonlithographictechnique to create microfluidic systems for biomedical applications. The results demonstratethe ability of the proposed method to perform cell free layer (CFL) measurements and theformation of microbubbles in continuous blood flow.
URI: https://hdl.handle.net/10216/107522
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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