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Author(s): Gerson Martin
Carla Pereira
Frank Pettersson
Henrik Saxén
Dmitry Y. Murzin
Alírio Rodrigues
Tapio Salmi
Title: Combination of Reaction and Separation in Heterogeneous Catalytic Hydrogenation of Ethylformate
Issue Date: 2015
Abstract: Continuous hydrogenation reaction of ethyl benzoylformate was studied over a (-)-cinchonidine (CD)-modified Pt/Al2O3 catalyst. The catalyst showed a good stability, and high enantioselectivity was achieved in the fixed-bed reactor. Chromatographic separation of (R)- and (S)-ethyl mandelate originating from a post-continuous hydrogenation reaction of ethyl benzoylformate over the (-)-CD-modified Pt/Al2O3 catalyst was investigated in the same reaction mixture. A commercial column filled with a chiral selector resin was chosen as a perspective preparative-scale adsorbent. Since adsorption equilibrium isotherms were linear within the entire investigated range of concentrations, they were determined by pulse experiments for the isomers present in a post-reaction mixture. Breakthrough curves were measured and described successfully by the dispersive plug-flow model with linear driving force approximation.
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/PEst-C/EQB/LA0020/2013/PROJECTO ESTRATÉGICO - LA 20 - 2013-2014/LA 20
info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/UID/EQU/50020/2013- POCI-01-0145-FEDER-006984/Laboratório de Processos de Separação e Reação - Laboratório de Catálise e Materiais/LSRE-LCM
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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