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Author(s): Lívia de Souza Simões
Daniel A. Madalena
Ana C. Pinheiro
José A. Teixeira
António A. Vicente
Óscar L. Ramos
Title: Micro- and nano bio-based delivery systems for food applications: In vitro behavior
Issue Date: 2017
Abstract: Micro- and nanoencapsulation is an emerging technology in the food field that potentially allows the improvement of food quality and human health. Bio-based delivery systems of bioactive compounds have a wide varietyof morphologies that influence their stability and functional performance. The incorporation of bioactive compounds in food products using micro- and nano-delivery systems may offer extra health benefits, beyond basicnutrition, once their encapsulation may provide protection against undesired environmental conditions (e.g.,heat, light and oxygen) along the food chain (including processing and storage), thus improving their bioavailability, while enabling their controlled release and target delivery. This review provides an overview of thebio-based materials currently used for encapsulation of bioactive compounds intended for food applications,as well as the main production techniques employed in the development of micro- and nanosystems. The behavior of such systems and of bioactive compounds entrapped into, throughout in vitro gastrointestinal systems, isalso tracked in a critical manner. Comparisons between various in vitro digestion systems (including the mainadvantages and disadvantages) currently in use, as well as correlations between the behavior of micro- andnanosystems studied through in vitro and in vivo systems were highlighted and discussed here for the firsttime. Finally, examples of bioactive micro- and nanosystems added to food simulants or to real food matricesare provided, together with a revision of the main challenges for their safe commercialization, the regulatory issues involved and the main legislation aspects.
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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