Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/104843
Full metadata record
DC FieldValueLanguage
dc.creatorFátima L. Mota
dc.creatorAntónio J. Queimada
dc.creatorAlfonsina E. Andreatta
dc.creatorSimão P. Pinho
dc.creatorEugénia A. Macedo
dc.date.accessioned2019-02-02T03:22:39Z-
dc.date.available2019-02-02T03:22:39Z-
dc.date.issued2012
dc.identifier.issn0378-3812
dc.identifier.othersigarra:64113
dc.identifier.urihttps://repositorio-aberto.up.pt/handle/10216/104843-
dc.description.abstractThe A-UNIFAC, UNIFAC, and NRTL-SAC models are used to predict solubility in pure solvents of a set of drug-like molecules. To apply A-UNIFAC, a new set of residual interaction parameters between the -ACOH group and six other groups had to be estimated. The solute model parameters of NRTL-SAC were also estimated for this set of molecules. NRTL-SAC showed better performance at 298.15 K. with an average absolute deviation of 37.6%. Solubility dependence with temperature was also studied: all models presented average deviations around 40%. In general, there is an improvement given by the A-UNIFAC over the UNIFAC in aqueous systems, proving the importance of taking association into account. The reference solvent approach was also applied improving the results. Solubility in pure solvents can now be predicted with an average deviation around 35.2%. This approach reduces differences previously found between the three models, being a powerful methodology.
dc.language.isoeng
dc.relationinfo:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Programa de Financiamento Plurianual de Unidades de I&D/PEst-C/EQB/LA0020/2011/Projeto Estratégico-LA 20 - 2011-2012/LA 20
dc.rightsrestrictedAccess
dc.subjectCiências Tecnológicas, Ciências da engenharia e tecnologias
dc.subjectTechnological sciences, Engineering and technology
dc.titleCalculation of drug-like molecules solubility using predictive activity coefficient models
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Engenharia
dc.identifier.doi10.1016/j.fluid.2012.02.003
dc.identifier.authenticusP-002-9YS
dc.subject.fosCiências da engenharia e tecnologias
dc.subject.fosEngineering and technology
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
64113.pdf
  Restricted Access
419.82 kBAdobe PDF    Request a copy from the Author(s)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.