Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/104681
Full metadata record
DC FieldValueLanguage
dc.creatorSusana P. Lopes
dc.creatorNuno F. Azevedo
dc.creatorMaria O. Pereira
dc.date.accessioned2019-04-15T23:13:11Z-
dc.date.available2019-04-15T23:13:11Z-
dc.date.issued2014
dc.identifier.issn2314-6133
dc.identifier.othersigarra:104737
dc.identifier.urihttps://hdl.handle.net/10216/104681-
dc.description.abstractConcurrent to conventional bacterial pathogens, unusual microbes are emerging from cystic fibrosis (CF) airways. Nonetheless, little is known about the contribution of these newly microbes to the resilience of CF-associated biofilms, particularly under variable-oxygen concentrations that are known to occur in vivo in the mucus of CF patients. Two CF-emergent bacterial species, Inquilinus limosus and Dolosigranulum pigrum, and the major pathogen Pseudomonas aeruginosa were studied in terms of biofilm development and antibiotic susceptibilities under in vitro atmospheres with different oxygen availabilities. All species were able to develop in vitro biofilms under different oxygen-available environments, with D. pigrum accumulating high amounts of biomass and respiratory activities. When established, biofilms were of difficult eradication, with antibiotics losing their effectiveness in comparison with the corresponding planktonic populations. Surprisingly, biofilms of each emergent organism displayed multidrug resistance under aerobic environments, enduring even in low-oxygen atmospheres. This study suggests a potential prospect on the impact of nonconventional organisms I. limosus and D. pigrum on CF lung infections, demonstrating capacity to adapt to biofilm mode of life under restricted-oxygen atmospheres resembling CF airways, which may ultimately endanger the efficacy of currently used antibiotic regimens.
dc.language.isoeng
dc.relationinfo:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/PEst-C/EQB/UI0511/2013/PROJECTO ESTRATÉGICO - UI 511 - 2013-2014/UI0511
dc.rightsrestrictedAccess
dc.subjectOutras ciências médicas
dc.subjectOther medical sciences
dc.titleEmergent bacteria in cystic fibrosis: In vitro biofilm formation and resilience under variable oxygen conditions
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Engenharia
dc.identifier.doi10.1155/2014/678301
dc.identifier.authenticusP-009-DFA
dc.subject.fosCiências médicas e da saúde::Outras ciências médicas
dc.subject.fosMedical and Health sciences::Other medical sciences
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
104737.pdfArtigo original publicado1.5 MBAdobe PDFThumbnail
View/Open
104737.1.pdf
  Restricted Access
Artigo original publicado1.5 MBAdobe PDF    Request a copy from the Author(s)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.