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Author(s): Ana Meireles
Manuel Simões
Title: Metabolic Control Analysis and its Applications
Issue Date: 2014
Abstract: Metabolic Engineering (ME) provides the know-how for the reconstruction of3 microorganisms, in order to provide higher production rates of biotechnological4 products and increase their potential application in several industries, particularly those5 pharmaceutical, food and environmental. However, microbial metabolic cell6 reconstruction has limitations. Metabolic Control Analysis (MCA) allows the evaluation7 of the reliability of the changes performed by ME, emphasizing the importance of the8 whole pathways rather than individual pathway reactions resulting from simple flux9 analysis. This led to an increased emphasis on the regulatory structure of the network.10 The use of MCA becomes indispensable to quantify metabolic parameters, particularly11 those related with direct genetic modifications. However, this type of analysis is not a12 common practice. In the present study MCA is exemplified as a tool of ME, being13 demonstrated its practical application in drug delivery and in the production of three14 relevant biotechnological products (penicillin V, l-lysine and glycerol).
Subject: Ciências Tecnológicas, Ciências da engenharia e tecnologias
Technological sciences, Engineering and technology
Scientific areas: Ciências da engenharia e tecnologias
Engineering and technology
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/PEst-C/EQB/UI0511/2013/PROJECTO ESTRATÉGICO - UI 511 - 2013-2014/UI0511
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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