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Author(s): Francisco D. C. Guerra Liberal
Adriana Alexandre S. Tavares
João Manuel R. S. Tavares
Title: Computational modeling of radiobiological effects in bone metastases for different radionuclides
Issue Date: 2017
Abstract: : Computational simulation is a simple and practical way to study and to compare a variety ofradioisotopes for different medical applications, including the palliative treatment of bone metastases. Thisstudy aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use orunder research for treatment of bone metastases using computational methods.Methods: Computational models were used to estimate the radiation-induced cellular effects (VirtualCell Radiobiology algorithm) post-irradiation with selected particles emitted by Strontium-89 (89Sr),Samarium-153 (153Sm), Lutetium-177 (177Lu), and Radium-223 (223Ra).Results: Cellular kinetics post-irradiation using 89Sr β- particles, 153Sm β− particles, 177Lu β− particles and 223Raα particles showed that the cell response was dose- and radio- nuclide-dependent. 177Lu beta minus particlesand, in particular, 223Ra alpha particles, yielded the lowest survival fraction of all investigated particles.Conclusions: 223Ra alpha particles induced the highest cell death of all investigated particles on metastaticprostate cells in comparison to irradiation with β− radionuclides, two of the most frequently used radionuclidesin the palliative treatment of bone metastases in clinical routine practice. Moreover, the data obtained suggestthat the used computational methods might provide some perception about cellular effects following irradiationwith different radionuclides.
Subject: Ciências Tecnológicas, Ciências médicas e da saúde
Technological sciences, Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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