Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/103578
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dc.creatorJoana Barros
dc.creatorLiliana Grenho
dc.creatorCândida M. Manuel
dc.creatorCarla Ferreira
dc.creatorLuís F. Melo
dc.creatorOlga C. Nunes
dc.creatorFernando J. Monteiro
dc.creatorMaria P. Ferraz
dc.date.accessioned2022-09-12T00:41:26Z-
dc.date.available2022-09-12T00:41:26Z-
dc.date.issued2013
dc.identifier.issn1139-6709
dc.identifier.othersigarra:93607
dc.identifier.urihttps://hdl.handle.net/10216/103578-
dc.description.abstractSurfaces of medical implants are generally designed to encourage soft- and/or hard-tissue adherence, eventually leading to tissue- or osseo-integration. Unfortunately, this feature may also encourage bacterial adhesion and biofilm formation. To understand the mechanisms of bone tissue infection associated with contaminated biomaterials, a detailed understanding of bacterial adhesion and subsequent biofilm formation on biomaterial surfaces is needed. In this study, a continuous-flow modular reactor composed of several modular units placed in parallel was designed to evaluate the activity of circulating bacterial suspensions and thus their predilection for biofilm formation during 72 h of incubation. Hydroxyapatite discs were placed in each modular unit and then removed at fixed times to quantify biofilm accumulation. Biofilm formation on each replicate of material, unchanged in structure, morphology, or cell density, was reproducibly observed. The modular reactor therefore proved to be a useful tool for following mature biofilm formation on different surfaces and under conditions similar to those prevailing near human-bone implants.
dc.language.isoeng
dc.relationinfo:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/PTDC/SAU-BMA/111233/2009/NaNOBiofilm - Superfícies de nanohidroxiapatite com caracteristicas antiobacterianas para prevenção de infecção óssea associada a biofilmes/NaNOBiofilm
dc.rightsrestrictedAccess
dc.subjectCiências Naturais, Ciências biológicas
dc.subjectNatural sciences, Biological sciences
dc.titleA modular reactor to simulate biofilm development in orthopedic materials
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Engenharia
dc.identifier.doi10.2436/20.1501.01.193
dc.identifier.authenticusP-006-JWB
dc.subject.fosCiências exactas e naturais::Ciências biológicas
dc.subject.fosNatural sciences::Biological sciences
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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