Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/103192
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dc.creatorG. Ruphuy
dc.creatorA. Saralegi
dc.creatorJ. C. Lopes
dc.creatorM. M. Dias
dc.creatorM. F. Barreiro
dc.date.accessioned2019-08-14T23:09:02Z-
dc.date.available2019-08-14T23:09:02Z-
dc.date.issued2016
dc.identifier.issn0921-8831
dc.identifier.othersigarra:180241
dc.identifier.urihttps://hdl.handle.net/10216/103192-
dc.description.abstractIn this work nano-hydroxyapatite/chitosan (n-HAp/CS) hybrid microparticles were prepared by spray drying following a methodology where, in a first step, aqueous nanodispersions of n-HAp in the presence of chitosan were produced by fast stirring at pH values below and above chitosan pKa (5.5 and 7.0, respectively). The mixing system used allowed the production of homogeneous and stable nanodispersions, and the subsequent spray-dried microparticles, incorporating highly pure HAp nanoparticles of approximately 50 nm, were successfully produced without degrading the organic component, chitosan. Comparatively with the n-HAp/CS-7.0, the n-HAp/CS-5.5 dispersions were characterized by a lower particle size and a higher zeta potential, being then more stable. Differences in the spray-dried microparticles were also evident from a morphological point of view. HApCS-5.5 microparticles, which present an average size in volume of 15.8 mu m and n-HAp crystals homogenously distributed, were found to be preferred over the HApCS-7.0 counterparts, which require an extra step in the productive process and presented a tendency to form large agglomerates. Both prepared hybrid particles presented similar composition to that one of natural bone (HAp/CS of 70/30) and no traces of KCl salts were observed if a washed n-HAp paste was used.
dc.language.isoeng
dc.relationinfo:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/UID/EQU/50020/2013- POCI-01-0145-FEDER-006984/Laboratório de Processos de Separação e Reação - Laboratório de Catálise e Materiais/LSRE-LCM
dc.relationinfo:eu-repo/grantAgreement/Autoriadade de Gestão do Programa Operacional Regional do Norte/Programas Integrados de IC&DT/ NORTE-07-0124-FEDER-000013/Mixing in Chemical Reactors /LSRE/LCM LA - RL2_P2
dc.rightsrestrictedAccess
dc.subjectEngenharia química, Tecnologia de materiais, Engenharia química
dc.subjectChemical engineering, Materials technology, Chemical engineering
dc.titleSpray drying as a viable process to produce nano-hydroxyapatite/chitosan (n-HAp/CS) hybrid microparticles mimicking bone composition
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Engenharia
dc.identifier.doi10.1016/j.apt.2016.02.010
dc.identifier.authenticusP-00K-DDN
dc.subject.fosCiências da engenharia e tecnologias::Engenharia química
dc.subject.fosEngineering and technology::Chemical engineering
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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