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Author(s): Klara Slezakova
Marta Oliveira
Maria José Alves
Adília Fernandes
João Paulo Teixeira
Cristina Delerue Matos
Maria do Carmo Pereira
Simone Morais
Title: Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites
Issue Date: 2016-05-08
Abstract: The concentrations of six urinary monohydroxyl metabolites (OH-PAHs) of polycyclic aromatic hydrocarbons, namely 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene (10HPy), and 3-hydroxybenzo[a]pyrene, were assessed in the post-shift urine of wildland firefighters involved in fire combat activities at six Portuguese fire corporations, and compared with those of non-exposed subjects. Overall, median levels of urinary individual and total OH-PAHs (Sigma OH-PAHs) suggest an increased exposure to polycyclic aromatic hydrocarbons during firefighting activities with Sigma OH-PAH levels in exposed firefighters 1.7-35 times higher than in non-exposed ones. Urinary 1-hydroxynaphthalene and/or 1-hydroxyacenapthene were the predominant compounds, representing 63-98% of Sigma OH-PAHs, followed by 2-hydroxyfluorene (1-17%), 1-hydroxyphenanthrene (1-13%), and 10HPy (0.3-10%). A similar profile was observed when gender discrimination was considered. Participation in fire combat activities promoted an increase of the distribution percentage of 1-hydroxynaphthalene and 1-hydroxyacenaphthene, while contributions of 1-hydroxyphenanthrene and 10HPy decreased. The detected urinary 10HPy concentrations (1.73 x 10(-2) to 0.152 mu mol/mol creatinine in exposed subjects versus 1.21 x 10(-2) to 5.44 x 10(-2) mu mol/mol creatinine in non-exposed individuals) were lower than the benchmark level (0.5 mu mol/mol creatinine) proposed by the American Conference of Governmental Industrial Hygienists. This compound, considered the biomarker of exposure to PAHs, was the less abundant one from the six analyzed biomarkers. Thus. the inclusion of other metabolites, in addition to 10HPy, in future studies is suggested to better estimate firefighters' occupational exposure to PAHs. Moreover, strong to moderate Spearman correlations were observed between individual compounds and Sigma OH-PAHs corroborating the prevalence of an emission source.
Subject: Ciências do ambiente, Ciências da saúde
Environmental science, Health sciences
Scientific areas: Ciências médicas e da saúde::Ciências da saúde
Medical and Health sciences::Health sciences
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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