Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/103023
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DC Field | Value | Language |
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dc.creator | Joana A. Loureiro | |
dc.creator | Stephanie Andrade | |
dc.creator | Ana Duarte | |
dc.creator | Ana Rute Neves | |
dc.creator | Joana Fontes Queiroz | |
dc.creator | Claúdia Nunes | |
dc.creator | Emmanuel Sevin | |
dc.creator | Laurence Fenart | |
dc.creator | Fabien Gosselet | |
dc.creator | Manuel A. N. Coelho | |
dc.creator | Maria do Carmo Pereira | |
dc.date.accessioned | 2022-09-07T20:30:12Z | - |
dc.date.available | 2022-09-07T20:30:12Z | - |
dc.date.issued | 2017 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.other | sigarra:185461 | |
dc.identifier.uri | https://hdl.handle.net/10216/103023 | - |
dc.description.abstract | The aggregation of amyloid- peptide (A) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer's disease (AD). Various natural compounds have been suggested as therapeutics for AD. Among these compounds, resveratrol has aroused great interest due to its neuroprotective characteristics. Here, we provide evidence that grape skin and grape seed extracts increase the inhibition effect on A aggregation. However, after intravenous injection, resveratrol is rapidly metabolized into both glucuronic acid and sulfate conjugations of the phenolic groups in the liver and intestinal epithelial cells (within less than 2 h), which are then eliminated. In the present study, we show that solid lipid nanoparticles (SLNs) functionalized with an antibody, the anti-transferrin receptor monoclonal antibody (OX26 mAb), can work as a possible carrier to transport the extract to target the brain. Experiments on human brain-like endothelial cells show that the cellular uptake of the OX26 SLNs is substantially more efficient than that of normal SLNs and SLNs functionalized with an unspecific antibody. As a consequence, the transcytosis ability of these different SLNs is higher when functionalized with OX-26. | |
dc.language.iso | eng | |
dc.relation | info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/PTDC/QUI-BIQ/118076/2010/Liposomas funcionalizados com anticorpos para a doença de Alzheimer/PTDC/QUI-BIQ/118076/2010 | |
dc.relation | info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE | |
dc.relation | info:eu-repo/grantAgreement/Autoridade de Gestão do Programa Operacional Regional do Norte/Programas Integrados de IC&DT/NORTE-07-0124-FEDER-000025/(Bio) Chemical Engineering: Multi-Scale Approaches for Sustainable Environment and Health/LEPAE/CEFT - RL2 | |
dc.rights | openAccess | |
dc.title | Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer's Disease | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Faculdade de Engenharia | |
dc.identifier.doi | 10.3390/molecules22020277 | |
dc.identifier.authenticus | P-00M-JZ9 | |
Appears in Collections: | FEUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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185461.pdf | Artigo original publicado | 3.86 MB | Adobe PDF | View/Open |
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