Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/102622
Author(s): Patrícia Cruz
Fernando Rocha
A. Ferreira
Title: Effect of operating conditions on batch and continuous paracetamol crystallization in an oscillatory flow mesoreactor
Issue Date: 2016-11-10
Abstract: The batch and continuous crystallization of paracetamol from aqueous solutions is studied in a novel oscillatory flow mesoreactor equipped with smooth periodic constrictions. The aim of this study is to evaluate the influence of the operating and thermodynamic variables on the size of the crystals for enhanced direct crystallization of micronized powders. It was found that mixing intensity, supersaturation and temperature determine the crystal size properties. Evaluating the results according to the classical nucleation theory, it was observed that the kinetic and the thermodynamic parameters are mainly influenced by the mixing intensity and by the crystallization temperature, respectively. The continuous-flow operation mode was revealed to be more suitable in the production of inhalable size particles because it provides smaller residence times and reduced friction, breakage and aggregation phenomena. Growth kinetic data were also obtained. This new reactor showed great potential to be used for direct crystallization of this drug for pulmonary drug delivery.
URI: https://hdl.handle.net/10216/102622
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE
info:eu-repo/grantAgreement/Comissão de Coordenação e Desenvolvimento Regional do Norte/P2020|Norte2020-Projetos Integrados ICDT/NORTE-01-0145-FEDER-000005/LEPABE-2-ECO-INNOVATION/LEPABE-2-ECO-INNOVATION
info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/P2020|COMPETE - Projetos em Todos os Domínios Científicos/PTDC/QEQ-PRS/3787/2014 - POCI-01-0145-FEDER-016816/Cristalização em contínuo de princípios ativos/CrystalFlow
info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Investigador FCT/IF/01087/2014/CP1249/CT0001/Projeto de investigação exploratória/IF/01087/2014/CP1249/CT0001
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
180082.pdf
  Restricted Access
Artigo original publicado2.46 MBAdobe PDF    Request a copy from the Author(s)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.