Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/100581
Author(s): | Goncalves, AS Appelberg, R |
Title: | Effects of recombinant granulocyte-colony stimulating factor administration during Mycobacterium avium infection in mice |
Issue Date: | 2001 |
Abstract: | Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes. Here we evaluated a possible protective role of this molecule in a mouse model of mycobacterial infection. The administration of recombinant G-CSF promoted an extensive blood neutrophilia but failed to improve the course of Mycobacterium avium infection in C57Bl/6 or beige mice. G-CSF administration also failed to improve the efficacy of a triple chemotherapeutic regimen (clarithromycin + ethambutol + rifabutin). G-CSF treatment did not protect interleukin-10 gene disrupted mice infected with M. avium. Spleen cells from infected mice treated with G-CSF had a decreased priming for antigen-specific production of interferon gamma compared to control infected mice. Our data do not substantiate previous reports on the protective activity of G-CSF in antimycobacterial immunity using mouse models. |
Subject: | Infecções, Medicina básica Infections, Basic medicine |
Scientific areas: | Ciências médicas e da saúde::Medicina básica Medical and Health sciences::Basic medicine |
URI: | https://hdl.handle.net/10216/100581 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | ICBAS - Artigo em Revista Científica Internacional |
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File | Description | Size | Format | |
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88546.octet-stream Restricted Access | 128.41 kB | Unknown | Request a copy from the Author(s) |
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