Utilize este identificador para referenciar este registo: https://hdl.handle.net/10216/97785
Autor(es): Helder Cardoso Cruz
Mafalda Sousa
Joana B Vieira
Deolinda Lima
Vasco Galhardo
Título: Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain
Data de publicação: 2013
Resumo: The medial prefrontal cortex (mPFC) and the mediodorsal thalamus (MD) form interconnected neural circuits that are important for spatial cognition and memory, but it is not known whether the functional connectivity between these areas is affected by the onset of an animal model of inflammatory pain. To address this issue, we implanted 2 multichannel arrays of electrodes in the mPFC and MD of adult rats and recorded local field potential activity during a food-reinforced spatial working memory task. Recordings were performed for 3 weeks, before and after the establishment of the pain model. Our results show that inflammatory pain caused an impairment of spatial working memory performance that is associated with changes in the activity of the mPFC-MD circuit; an analysis of partial directed coherence between the areas revealed a global decrease in the connectivity of the circuit. This decrease was observed over a wide frequency range in both the frontothalamic and thalamofrontal directions of the circuit, but was more evident from MD to mPFC. In addition, spectral analysis revealed significant oscillations of power across frequency bands, namely with a strong theta component that oscillated after the onset of the painful condition. Finally, our data revealed that chronic pain induces an increase in theta/gamma phase coherence and a higher level of mPFC-MD coherence, which is partially conserved across frequency bands. The present results demonstrate that functional disturbances in mPFC-MD connectivity are a relevant cause of deficits in pain-related working memory.
Assunto: Medicina clínica
Clinical medicine
Áreas do conhecimento: Ciências médicas e da saúde::Medicina clínica
Medical and Health sciences::Clinical medicine
URI: https://hdl.handle.net/10216/97785
Tipo de Documento: Artigo em Revista Científica Internacional
Condições de Acesso: restrictedAccess
Aparece nas coleções:FMUP - Artigo em Revista Científica Internacional

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