Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10216/97316
Autor(es): | quezada, elias delogu, giovanna picciau, carmen santana, lourdes podda, gianni borges, fernanda garcia-morales, veronica vina, dolores orallo, francisco |
Título: | Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins |
Data de publicação: | 2010 |
Resumo: | A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives. |
URI: | https://repositorio-aberto.up.pt/handle/10216/97316 |
Tipo de Documento: | Artigo em Revista Científica Internacional |
Condições de Acesso: | restrictedAccess |
Aparece nas coleções: | FCUP - Artigo em Revista Científica Internacional |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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48504.pdf Restricted Access | 174.33 kB | Adobe PDF | Request a copy from the Author(s) |
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