Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10216/82067
Autor(es): | Joana Matos Filipa P da Cruz Elia Cabrita Jiri Gut Fatima Nogueira Virgilio E do Rosario Rui Moreira Philip J Rosenthal Miguel Prudencio Paula Gomes |
Título: | Novel Potent Metallocenes against Liver Stage Malaria |
Data de publicação: | 2012 |
Resumo: | Novel conjugates of the antimalarial drug primaquine (compound 1) with ferrocene, named primacenes, have been synthesized and screened for their activities against blood stage and liver stage malaria in vitro and host-vector transmission in vivo. Both transmission-blocking and blood-schizontocidal activities of the parent drug were conserved only in primacenes bearing a basic aliphatic amine group. Liver stage activity did not require this structural feature, and all metallocenes tested were comparable to or better than primaquine in this regard. Remarkably, the replacement of primaquine's aliphatic chain by hexylferrocene, as in compound 7, led to a similar to 45-fold-higher level activity against liver stage parasitemia than that of primaquine. |
Assunto: | Medicina básica Basic medicine |
Áreas do conhecimento: | Ciências médicas e da saúde::Medicina básica Medical and Health sciences::Basic medicine |
URI: | https://repositorio-aberto.up.pt/handle/10216/82067 |
Tipo de Documento: | Artigo em Revista Científica Internacional |
Condições de Acesso: | openAccess |
Licença: | https://creativecommons.org/licenses/by-nc/4.0/ |
Aparece nas coleções: | FCUP - Artigo em Revista Científica Internacional |
Este registo está protegido por Licença Creative Commons