Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/6960
Author(s): | Ricardo Jorge Dinis Oliveira Ant??nio Sarmento Paulo Reis Augusta Amaro Fernando Remi??o Maria L Bastos Felix Carvalho |
Title: | Acute paraquat poisoning - Report of a survival case following intake of a potential lethal dose |
Issue Date: | 2006 |
Abstract: | When properly used, paraquat (PQ) is a widely used bipyridil herbicide with a good safety record. Most cases of PQ poisoning result from intentional ingestion, with death resulting from hypoxemia secondary to lung fibrosis in moderate to severe poisonings. With high ingestion volumes (> 50 mL of a 20% wt/vol formulation), death results from multiple organ failure and cardiovascular collapse within 1 week after intoxication. The present report describes a successful clinical case regarding the intoxication of a 15-year-old girl by a presumed lethal dose of PQ. The adolescent ingested approximately 50 mL of a commercialized concentrate (20% wt/vol of dichloride salt) formulation of PQ. High serum and urinary levels of PQ confirmed the bad prognosis. However, the therapeutic protocol followed in the present clinical case led to a positive outcome. Besides the measures for decreasing PQ absorption and increasing its elimination, other protective procedures were applied in aiming to reduce the production of reactive oxygen species (ROS), to scavenge ROS, to repair ROS-induced lesions, and to reduce inflammation. The status-of-the-art concerning the biochemical and toxicological aspects of PQ poisoning and the pharmacologic basis of the respective treatment is also presented. |
URI: | https://hdl.handle.net/10216/6960 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by-nc/4.0/ |
Appears in Collections: | FFUP - Artigo em Revista Científica Internacional |
This item is licensed under a Creative Commons License